{"id":"W4406715937","doi":"10.1038/s41586-024-08468-9","title":"Genomics yields biological and phenotypic insights into bipolar disorder","year":2025,"lang":"en","type":"review","venue":"Nature","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Dalhousie University; Montreal Neurological Institute and Hospital; University of Toronto; Centre for Addiction and Mental Health; McGill University Health Centre","funders":"Medical Research Council; National Institutes of Health; National Institute of Mental Health; World Health Organization","keywords":"Bipolar disorder; Genetic architecture; Genome-wide association study; Biology; Genetic association; Genetic heterogeneity; Genetics; Genomics; Phenotype; Gene; Neuroscience; Genome; Genotype; Single-nucleotide polymorphism; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001563608,0.0003204639,0.0007918187,0.00008470281,0.0001186933,0.00001499116,0.0002659282,0.006268769,0.00001477861],"category_scores_gemma":[0.0004889314,0.0002314229,0.0002373497,0.0001442153,0.0000803315,0.000001000815,0.0003037943,0.001346165,0.00001068096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002893412,"about_ca_system_score_gemma":0.0002097145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006712198,"about_ca_topic_score_gemma":0.00004318235,"domain_scores_codex":[0.9986264,0.0002121545,0.000328935,0.0005536401,0.0000507551,0.0002280962],"domain_scores_gemma":[0.9992571,0.00009753392,0.0001698992,0.0003554665,0.00005531646,0.00006465425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000004745228,0.00003211282,0.0004722397,0.001207684,0.0002274008,0.000001422321,0.00001961961,0.000001335049,0.00003832744,0.0002870984,0.004654622,0.9930534],"study_design_scores_gemma":[0.00008695105,0.00006752783,0.0002340567,0.0002519097,0.0001404136,0.000005108922,0.000008027208,0.000002070208,0.000002687287,0.0004224006,0.9985351,0.0002437634],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000984914,0.9977284,0.0002214297,0.0000953186,0.0003306791,0.0003020159,0.000031886,0.000008245296,0.0002970785],"genre_scores_gemma":[0.0003385503,0.996205,0.0009280045,0.0004658648,0.0003330878,0.00004023829,0.0008627653,0.00001939272,0.0008070364],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9938805,"threshold_uncertainty_score":0.9950213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01321417889656057,"score_gpt":0.2983393477108355,"score_spread":0.285125168814275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}