{"id":"W4406730711","doi":"10.1002/btm2.10741","title":"Establishment of a chemoresistant laryngeal cancer cell model to study chemoresistance and chemosensitization responses via transcriptomic analysis and a tumor‐on‐a‐chip platform","year":2025,"lang":"en","type":"article","venue":"Bioengineering & Translational Medicine","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Royal Victoria Hospital; McGill University","funders":"National Institutes of Health","keywords":"Transcriptome; Cancer; Medicine; Cancer research; Biology; Internal medicine; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001691071,0.000177002,0.0002606012,0.0002150139,0.00004459918,0.000008211538,0.00006614178,0.0000522427,0.000006453066],"category_scores_gemma":[0.00002605606,0.0001691323,0.00004435365,0.000362512,0.00005560165,0.000009112843,0.00001457731,0.00004392859,6.589938e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002894174,"about_ca_system_score_gemma":0.00005529616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005512947,"about_ca_topic_score_gemma":0.0001293189,"domain_scores_codex":[0.9990227,0.00001329033,0.0002943332,0.0003372775,0.0001991201,0.000133341],"domain_scores_gemma":[0.9995947,0.00002597069,0.00005466926,0.0001697271,0.0000911932,0.00006376687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009091367,0.000122986,0.003253275,0.0001666759,0.0002817062,0.000001657923,0.0003244364,0.01463925,0.9793316,0.00009689438,0.0000301167,0.0008422457],"study_design_scores_gemma":[0.003211691,0.0003526265,0.3312898,0.0001741553,0.00105632,0.000002317593,0.0001593198,0.07197981,0.5912026,0.0001072728,0.0001197598,0.0003444014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9445284,0.002488954,0.05200322,0.0004371812,0.00003086708,0.000380854,0.00006336951,0.00001334954,0.00005378797],"genre_scores_gemma":[0.9982597,0.00007438638,0.001307883,0.0001321813,0.00003685085,0.00004080477,0.00008892478,0.0000145506,0.00004473286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3881291,"threshold_uncertainty_score":0.6897014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012864942404215,"score_gpt":0.2574500145159809,"score_spread":0.2473213650919387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}