{"id":"W4406732443","doi":"10.18632/aging.206188","title":"EpiAge: a next-generation sequencing-based ELOVL2 epigenetic clock for biological age assessment in saliva and blood across health and disease","year":2025,"lang":"en","type":"article","venue":"Aging","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Epigenetics; Saliva; Disease; Biology; Biological age; Medicine; Computational biology; Evolutionary biology; Genetics; Pathology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002667499,0.0008662472,0.0009479505,0.000646767,0.000335838,0.0009574129,0.001158209,0.001078972,0.003306886],"category_scores_gemma":[0.004735072,0.0004204043,0.0009825119,0.0005959018,0.0003587171,0.001016936,0.0008109798,0.0009121577,0.0007933442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007311019,"about_ca_system_score_gemma":0.00136594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01010979,"about_ca_topic_score_gemma":0.0144954,"domain_scores_codex":[0.9994127,0.000197307,0.00002515374,0.0002241745,0.00009106794,0.00004966743],"domain_scores_gemma":[0.9988419,0.0007318343,0.0001369416,0.00009243204,0.0001351211,0.00006175025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.001089203,0.0003238783,0.08004823,0.0005798819,0.0007521561,0.0003726619,0.0003633923,0.7018269,0.01615164,0.01868112,0.01100336,0.1688076],"study_design_scores_gemma":[0.00004952516,0.0001516813,0.006692089,0.000026875,0.0001148774,0.0001369741,0.00002416524,0.9758789,0.00257044,0.007497833,0.006806185,0.00005045156],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1420642,0.001981826,0.8376009,0.001190409,0.000329873,0.0002665416,0.008100764,0.004430711,0.004034942],"genre_scores_gemma":[0.7325543,0.001468516,0.2419381,0.0009808855,0.0002453727,0.001057823,0.008883633,0.0005793434,0.01229204],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01010979,"threshold_uncertainty_score":0.02010185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06267133372101853,"score_gpt":0.3595002112356528,"score_spread":0.2968288775146343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}