{"id":"W4406732443","doi":"10.18632/aging.206188","title":"EpiAge: a next-generation sequencing-based ELOVL2 epigenetic clock for biological age assessment in saliva and blood across health and disease","year":2025,"lang":"en","type":"article","venue":"Aging","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Epigenetics; Saliva; Disease; Biology; Biological age; Medicine; Computational biology; Evolutionary biology; Genetics; Pathology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003861781,0.0001183898,0.0001384052,0.00004222841,0.0001389479,0.00006428354,0.00005066501,0.00007487655,9.138828e-7],"category_scores_gemma":[0.0001464404,0.0001139757,0.00003172806,0.00007280579,0.00005156039,0.000003642317,0.00006015903,0.00006246821,7.635916e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002748179,"about_ca_system_score_gemma":0.0002736261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005862237,"about_ca_topic_score_gemma":0.0001634574,"domain_scores_codex":[0.9990264,0.00009858752,0.0002183334,0.000373012,0.00005119024,0.0002324512],"domain_scores_gemma":[0.9995878,0.00003841852,0.00006009506,0.000155045,0.00003098557,0.000127686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004372984,0.00007669463,0.1621377,0.0001639396,0.00002602736,0.000006787085,0.0001482913,0.0008566909,0.8170484,0.0004443748,0.00003699345,0.0190104],"study_design_scores_gemma":[0.008571481,0.00203877,0.4733146,0.0004162269,0.0001128645,0.000003539053,0.0008087128,0.07193576,0.424475,0.007545748,0.009510981,0.001266251],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9607072,0.01037975,0.02754103,0.0008986439,0.00005646941,0.0003677721,0.00001942003,0.000007949001,0.00002168346],"genre_scores_gemma":[0.9936156,0.0009963785,0.004070204,0.0008813778,0.00007140619,0.00006426204,0.0002557682,0.000009330827,0.00003572238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3925734,"threshold_uncertainty_score":0.4647796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06267133372101853,"score_gpt":0.3595002112356528,"score_spread":0.2968288775146343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}