{"id":"W4406734951","doi":"10.1007/s11886-025-02202-1","title":"The Accuracy of Technetium-99 m Pyrophosphate Imaging in Diagnosing Transthyretin Cardiac Amyloidosis and Its Impact on Patient Management","year":2025,"lang":"en","type":"review","venue":"Current Cardiology Reports","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Calgary General Hospital; Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"","keywords":"Medicine; Transthyretin; Single-photon emission computed tomography; Diagnostic accuracy; Cardiac amyloidosis; Pyrophosphate; Nuclear medicine; Radiology; Internal medicine; Nuclear magnetic resonance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006405473,0.0008709426,0.002221366,0.0003026349,0.0001548824,0.0000407909,0.0003223401,0.0003656888,0.000002748029],"category_scores_gemma":[0.0004191989,0.0005932661,0.00140658,0.0003350579,0.0002149134,0.00000790175,0.0004297909,0.0004033937,0.000002509662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001962097,"about_ca_system_score_gemma":0.0002407025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001516447,"about_ca_topic_score_gemma":0.000001924062,"domain_scores_codex":[0.9958383,0.0005548154,0.001427794,0.001252027,0.0002605103,0.0006665692],"domain_scores_gemma":[0.9970171,0.0005405659,0.001055197,0.001170143,0.00009745381,0.0001194911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003395144,0.00009602369,0.01848218,0.002868009,0.0009879321,0.000263932,0.00002123576,0.00003699776,0.00001815682,0.00001786358,0.001585189,0.9755885],"study_design_scores_gemma":[0.0004861792,0.0002998126,0.00608033,0.01113483,0.002452059,0.0002154273,0.00005489922,0.00000142225,0.0009928026,0.00003807875,0.9773003,0.000943848],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01440824,0.9809886,0.000009580388,0.00004114663,0.001555322,0.002474996,0.0001555958,0.00002487394,0.0003417055],"genre_scores_gemma":[0.07609836,0.9218702,0.00001367047,0.0000195188,0.0001045504,0.001438951,0.0003660489,0.00006127956,0.00002739717],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9757151,"threshold_uncertainty_score":0.9996518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.011982372505679,"score_gpt":0.3338849223167443,"score_spread":0.3219025498110653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}