{"id":"W4406741690","doi":"10.1016/j.kint.2025.01.009","title":"Melanocortin 5 receptor signaling protects against podocyte injury in proteinuric glomerulopathies","year":2025,"lang":"en","type":"article","venue":"Kidney International","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Multiple Sclerosis Center of Atlanta; National Institutes of Health; University of Toledo; National Institute of Diabetes and Digestive and Kidney Diseases; Mallinckrodt Pharmaceuticals; American Society of Nephrology","keywords":"Podocyte; Melanocortin; Endocrinology; Internal medicine; Biology; Medicine; Proteinuria; Hormone; Kidney","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001975778,0.00047921,0.000521389,0.0004032437,0.0001699463,0.0002711386,0.0002630752,0.0003926292,0.001384761],"category_scores_gemma":[0.0001147771,0.0001590038,0.0003774338,0.0001413837,0.0001921513,0.0002973339,0.000189304,0.0008746218,0.0002329157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001987754,"about_ca_system_score_gemma":0.0002532744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005195227,"about_ca_topic_score_gemma":0.0007970614,"domain_scores_codex":[0.9998524,0.00002436305,0.00001805663,0.00002456764,0.00003330764,0.00004740399],"domain_scores_gemma":[0.9999193,0.000004080843,0.00002122488,0.000009827972,0.000008673717,0.00003686849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002688968,0.0003613968,0.0004231663,0.000253105,0.0000619401,0.0001262398,0.00002357299,0.0001263,0.9834021,0.0001654669,0.0002604167,0.01210741],"study_design_scores_gemma":[0.0006968862,0.00896522,0.02842209,0.0000762753,0.0003037034,0.000696565,0.00008957059,0.001718742,0.9494218,0.0003229282,0.009257967,0.00002834948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873502,0.008091488,0.001915466,0.0002139533,0.0001324735,0.00005930371,0.0003509675,0.0003775911,0.001508404],"genre_scores_gemma":[0.9944016,0.0023547,0.0009727536,0.0001397401,0.00002886886,0.00004087216,0.0003927578,0.00001985009,0.001648852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001384761,"threshold_uncertainty_score":0.004632473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007522375508879125,"score_gpt":0.2777344669634921,"score_spread":0.270212091454613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}