{"id":"W4406750169","doi":"10.1007/s11011-024-01525-2","title":"Attenuating hyperammonemia preserves protein synthesis and muscle mass via restoration of perturbed metabolic pathways in bile duct-ligated rats","year":2025,"lang":"en","type":"article","venue":"Metabolic Brain Disease","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institutes of Health; Canadian Institutes of Health Research; Canadian Liver Foundation; Horizon Therapeutics; Mallinckrodt Pharmaceuticals; American College of Gastroenterology","keywords":"Hyperammonemia; Neurology; Bile duct; Internal medicine; Duct (anatomy); Medicine; Endocrinology; Chemistry; Neuroscience; Anatomy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002889707,0.001024596,0.0008741107,0.001006151,0.0005130908,0.0005653942,0.0006132398,0.0007538433,0.001876829],"category_scores_gemma":[0.000340604,0.0005149703,0.0005063685,0.0003993674,0.001561097,0.0008091458,0.0004581917,0.00172929,0.0004456275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000652388,"about_ca_system_score_gemma":0.0008609191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002455359,"about_ca_topic_score_gemma":0.00404527,"domain_scores_codex":[0.9997134,0.00003950563,0.00003664009,0.00006314451,0.00004373375,0.0001036792],"domain_scores_gemma":[0.9992365,0.00006290383,0.000237159,0.00009455509,0.00005801487,0.0003109326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01015516,0.000459023,0.0005393732,0.00007915267,0.00003756829,0.0001929328,0.00008162273,0.0002223177,0.9845207,0.0002315832,0.0001089458,0.003371658],"study_design_scores_gemma":[0.0003720661,0.00431232,0.006329759,0.00002331202,0.0001127046,0.0002058128,0.0002867815,0.001259686,0.9851039,0.0003438817,0.001613421,0.00003639011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970656,0.0005591556,0.001151942,0.0002691373,0.00008394043,0.00001881847,0.0002575266,0.0002207875,0.0003731371],"genre_scores_gemma":[0.9934734,0.000650265,0.001551731,0.0001433777,0.00003332358,0.00007078546,0.0003838172,0.00008466079,0.003608725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002455359,"threshold_uncertainty_score":0.006278634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009306730308816962,"score_gpt":0.2329597803449072,"score_spread":0.2236530500360902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}