{"id":"W4406750248","doi":"10.1007/s00204-024-03939-4","title":"A physiologically based pharmacokinetic (PBPK) model describing the kinetics of a commercial mixture α-, β-, and γ-hexabromocyclododecane exposure in mice","year":2025,"lang":"en","type":"article","venue":"Archives of Toxicology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institutes of Health","keywords":"Hexabromocyclododecane; Physiologically based pharmacokinetic modelling; Chemistry; Toxicokinetics; Pharmacokinetics; Environmental chemistry; Chromatography; Organic chemistry; Fire retardant; Pharmacology; Toxicity; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000130484,0.0001485083,0.0002950116,0.00007807046,0.00003620485,0.000004209259,0.0004366114,0.00008077806,0.0001196462],"category_scores_gemma":[0.0001690555,0.0001077081,0.00005404501,0.0002174818,0.000851044,0.00003470995,0.0003188724,0.0002166338,0.000001243575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002919579,"about_ca_system_score_gemma":0.00002871591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003751102,"about_ca_topic_score_gemma":0.0002503767,"domain_scores_codex":[0.9987986,0.0002300759,0.0003317539,0.0002462078,0.0001090418,0.0002843356],"domain_scores_gemma":[0.999059,0.0005381352,0.0001260438,0.0002236508,0.000001485536,0.00005168732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001871278,0.0002222278,0.004299185,0.00001390253,0.00001456959,0.000003342452,0.000650575,0.00463272,0.9446422,0.00008538995,0.00006524743,0.04518346],"study_design_scores_gemma":[0.001717168,0.0005132618,0.6694934,0.00006798999,0.00005231755,0.000007934193,0.00008341129,0.06190683,0.2616879,0.004244256,0.00005997174,0.0001655292],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916738,0.0001383586,0.002681347,0.00181015,0.00004741978,0.0002735099,0.00004750985,0.00001110359,0.003316755],"genre_scores_gemma":[0.9946257,0.00003213925,0.004339972,0.0009181382,0.000007956451,0.000006696812,7.207439e-7,0.000008333875,0.00006029347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6829543,"threshold_uncertainty_score":0.439221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02209056097241996,"score_gpt":0.2547112643636511,"score_spread":0.2326207033912311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}