{"id":"W4406750752","doi":"10.1186/s13229-024-00633-1","title":"Evolutionary constrained genes associated with autism spectrum disorder across 2,054 nonhuman primate genomes","year":2025,"lang":"en","type":"article","venue":"Molecular Autism","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Genome Canada","funders":"Medical Research Council; National Institutes of Health","keywords":"Autism spectrum disorder; Nonhuman primate; Primate; Genome; Biology; Neuropsychology; Gene; Autism; Evolutionary biology; Genetics; Computational biology; Psychology; Neuroscience; Developmental psychology; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005127462,0.0003606679,0.0007079522,0.002656339,0.001098438,0.0008411178,0.0003513029,0.0004211082,0.002592638],"category_scores_gemma":[0.001367499,0.0002347015,0.000871168,0.002907249,0.0003903824,0.0002115511,0.0009519277,0.0005306117,0.0002658384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003138961,"about_ca_system_score_gemma":0.000401139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004657335,"about_ca_topic_score_gemma":0.009747444,"domain_scores_codex":[0.999341,0.0001270474,0.00003637248,0.0003305862,0.00009675104,0.00006837443],"domain_scores_gemma":[0.9993163,0.000343305,0.0001537237,0.0000736329,0.00004850374,0.00006460986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002185781,0.0001427964,0.5689449,0.001540312,0.005478191,0.003848708,0.003348988,0.007192823,0.3430437,0.002241855,0.003715625,0.05831626],"study_design_scores_gemma":[0.00004752507,0.000112718,0.9756833,0.0001063731,0.000787179,0.002103344,0.000645588,0.0046455,0.002634906,0.001212533,0.01198498,0.00003598441],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914694,0.001176512,0.001057066,0.00007332574,0.000007497329,0.000009910405,0.005373971,0.00006600579,0.0007662953],"genre_scores_gemma":[0.9779895,0.0007444352,0.005321588,0.000155072,0.00001593308,0.0000633075,0.01513875,0.00009093252,0.000480413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004657335,"threshold_uncertainty_score":0.009260416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01175502544150204,"score_gpt":0.2887368409164224,"score_spread":0.2769818154749203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}