{"id":"W4406752915","doi":"10.7554/elife.95576.2.sa1","title":"Reviewer #2 (Public Review): AXONAL distribution of mitochondria maintains neuronal autophagy during aging via eIF2β","year":2025,"lang":"en","type":"peer-review","venue":"","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; National Institute of General Medical Sciences; Directorate for Biological Sciences; National Institutes of Health; Novartis Foundation; Tokyo Metropolitan University; NOVARTIS Foundation (Japan) for the Promotion of Science; Japan Foundation for Aging and Health; Hoansha Foundation","keywords":"Autophagy; Mitochondrion; Neuroscience; Cell biology; Distribution (mathematics); Biology; Biochemistry; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003918717,0.0004879221,0.0008734729,0.00008228605,0.0001004547,0.00002482882,0.0004800983,0.0002979506,0.001280096],"category_scores_gemma":[0.00157643,0.0004453559,0.0007690035,0.0003148109,0.0001017354,0.000007889291,0.0003606362,0.000265697,0.00002338778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007184578,"about_ca_system_score_gemma":0.0006011736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001754226,"about_ca_topic_score_gemma":0.00001741508,"domain_scores_codex":[0.9969896,0.0002709758,0.001032906,0.0007888582,0.0005140016,0.0004036711],"domain_scores_gemma":[0.9969125,0.00002058748,0.0005417482,0.0009683578,0.001318503,0.0002382961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001413755,0.00008677067,0.00005145384,0.02526296,0.0001083515,0.000004114808,3.990383e-7,0.00000268746,0.001998497,0.0001352894,0.9670613,0.005274026],"study_design_scores_gemma":[0.0003707313,0.00003942563,0.002306733,0.01027759,0.0003355173,0.00001333133,6.194495e-7,0.00001788161,0.001042167,0.00001648302,0.9851853,0.0003942165],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008519616,0.9424514,0.007820613,0.03459317,0.004082306,0.002499092,0.002239667,0.00007785692,0.005383907],"genre_scores_gemma":[0.002663009,0.5100679,0.0003428448,0.01836407,0.001769629,0.0003065147,0.05741482,0.00008100102,0.4089902],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4323835,"threshold_uncertainty_score":0.9997998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01263960647184413,"score_gpt":0.2849867980959217,"score_spread":0.2723471916240776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}