{"id":"W4406760478","doi":"10.1093/oncolo/oyae356","title":"Pooled safety analysis and management of sotorasib-related adverse events in <i>KRAS</i> G12C-mutated advanced non-small cell lung cancer","year":2025,"lang":"en","type":"article","venue":"The Oncologist","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre","funders":"National Cancer Institute; Amgen","keywords":"KRAS; Medicine; Oncology; Lung cancer; Cancer; Adverse effect; Internal medicine; Pooled analysis; Cancer research; Colorectal cancer; Meta-analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04298883,0.001203799,0.003935396,0.001760035,0.0002271644,0.002031454,0.0007735839,0.0009554074,0.004191739],"category_scores_gemma":[0.05264467,0.0005240154,0.01401394,0.00180783,0.0003744601,0.0009578272,0.0009836218,0.0009650917,0.0006169251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001007276,"about_ca_system_score_gemma":0.001639012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005938349,"about_ca_topic_score_gemma":0.0008869151,"domain_scores_codex":[0.9740645,0.01748936,0.003298466,0.001890317,0.002928484,0.0003289686],"domain_scores_gemma":[0.9723901,0.01237658,0.008912075,0.0027429,0.003248125,0.0003301222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.1054542,0.0004235014,0.04901992,0.03962021,0.5631431,0.0002287846,0.0002404622,0.008875958,0.006232831,0.001002119,0.0110047,0.2147543],"study_design_scores_gemma":[0.03828278,0.031902,0.1836839,0.007105479,0.6625443,0.001516067,0.0001895861,0.01124095,0.009326926,0.00549266,0.04842647,0.0002889266],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4340785,0.417929,0.06785394,0.004077806,0.001587187,0.01004537,0.04242539,0.001649714,0.02035292],"genre_scores_gemma":[0.9431826,0.02756485,0.009353376,0.00194669,0.000771443,0.003681451,0.01176033,0.0001739762,0.001565231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04298883,"threshold_uncertainty_score":0.2273493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00639325103339201,"score_gpt":0.3250241704090374,"score_spread":0.3186309193756454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}