{"id":"W4406772134","doi":"10.1002/pbc.31516","title":"Access to CARe: A Narrative of Real‐World Medical Decision‐Making to Access Chimeric Antigen Receptor (CAR) T‐Cell Therapy in Children, Adolescents, and Young Adults","year":2025,"lang":"en","type":"review","venue":"Pediatric Blood & Cancer","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute; Intramural Research Program; NIH Clinical Center; National Institutes of Health","keywords":"Chimeric antigen receptor; Medicine; Narrative review; Refractory (planetary science); Clinical trial; Oncology; Pediatrics; Immunotherapy; Intensive care medicine; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003658882,0.0005240488,0.0007075162,0.001094902,0.0007192468,0.002762592,0.0007697479,0.002690131,0.002050679],"category_scores_gemma":[0.009815882,0.0002729945,0.0005875687,0.001454217,0.001304681,0.003141832,0.001437965,0.003434577,0.0004169265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002868869,"about_ca_system_score_gemma":0.005575738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003134074,"about_ca_topic_score_gemma":0.008163287,"domain_scores_codex":[0.9980685,0.001304978,0.0001812183,0.00008870969,0.0002615262,0.00009509677],"domain_scores_gemma":[0.9944425,0.004586533,0.0004045037,0.00005575508,0.000343124,0.0001676721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"qualitative","study_design_scores_codex":[0.0001079189,0.00007376006,0.0007568135,0.04005733,0.000236928,0.001788444,0.006573191,0.001027335,0.0003654926,0.09479295,0.1260074,0.7282125],"study_design_scores_gemma":[0.00002428782,0.00005610714,0.0006331576,0.05201186,0.0001554172,0.003208951,0.003141023,0.0002033315,0.0001586007,0.01238862,0.9279734,0.00004518149],"study_design_candidate":"qualitative","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008030404,0.969884,0.0005152788,0.02290316,0.0007385087,0.00002586669,0.00003488177,0.000006413986,0.005088763],"genre_scores_gemma":[0.0134882,0.9762907,0.001190731,0.00734305,0.0007418081,0.00006262062,0.00003744769,0.000005793657,0.0008395512],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003658882,"threshold_uncertainty_score":0.02081525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02856832625672536,"score_gpt":0.4049604464300942,"score_spread":0.3763921201733689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}