{"id":"W4406778471","doi":"10.1007/s10549-024-07580-8","title":"A Canadian real-world, multi-center, prospective, observational study assessing the treatment duration, the treatment sequence, and the overall survival for patients treated with endocrine therapy ± targeted therapy in HR + HER2-negative advanced breast cancer","year":2025,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Novartis (Canada); Kingston Health Sciences Centre; McGill University Health Centre; Jewish General Hospital; Ottawa Hospital; Saskatchewan Cancer Agency; Ottawa Regional Cancer Foundation; Windsor Regional Hospital; Western University; Grand River Hospital; Centre hospitalier universitaire de Québec","funders":"Novartis Pharmaceuticals Canada","keywords":"Medicine; Observational study; Oncology; Targeted therapy; Survival analysis; Internal medicine; Prospective cohort study; Endocrine system; Cancer; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009441251,0.0004453264,0.000517706,0.0005614742,0.001849529,0.0007836325,0.000802683,0.0005301132,0.001548444],"category_scores_gemma":[0.002139327,0.0003430103,0.000794791,0.002320595,0.0005137126,0.0003734058,0.0005377413,0.0007725279,0.0001402143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01375111,"about_ca_system_score_gemma":0.01756211,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9045313,"about_ca_topic_score_gemma":0.9386836,"domain_scores_codex":[0.9991178,0.0001117084,0.00006085355,0.0002189125,0.0002729942,0.0002176753],"domain_scores_gemma":[0.9977607,0.0001516602,0.0009846509,0.0001076366,0.0005218571,0.000473643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006514892,0.000113683,0.9952205,0.00007418907,0.0001954167,0.0000451487,0.0001960712,0.0001034366,0.0002540398,0.00004747575,0.0005877271,0.002510709],"study_design_scores_gemma":[0.0001125328,0.0002731301,0.9976477,0.00003390184,0.0001572558,0.0001122987,0.0003583764,0.0003031674,0.00006276034,0.00002029432,0.0009027196,0.00001602112],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995724,0.0006562539,0.0001004786,0.0001535899,0.000009477601,0.00007920204,0.002692893,0.000004257131,0.0005798561],"genre_scores_gemma":[0.997134,0.0003828504,0.0003057871,0.0001347651,0.00001303849,0.00005059304,0.001725208,0.000002597395,0.000251124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0954687,"threshold_uncertainty_score":0.1920618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08490122213785031,"score_gpt":0.4171629806915637,"score_spread":0.3322617585537134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}