{"id":"W4406783172","doi":"10.1007/s40005-024-00718-2","title":"Thioester platform to develop potential nanomedicines for breast cancer therapy","year":2025,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Investigation","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Breast cancer; Cancer therapy; Thioester; Medicine; Cancer; Computational biology; Internal medicine; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002330827,0.00009095408,0.0001204707,0.00008483329,0.00004665293,0.00002327877,0.0001385183,0.00007900413,0.00003022599],"category_scores_gemma":[0.00006894949,0.00006869582,0.00006169795,0.0001411044,0.00005157525,0.00001285256,0.00002832385,0.00008427257,0.000001751818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002289307,"about_ca_system_score_gemma":0.0002736175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002897706,"about_ca_topic_score_gemma":0.00000299138,"domain_scores_codex":[0.999335,0.00002041469,0.0002920957,0.0001123183,0.0001072084,0.0001329575],"domain_scores_gemma":[0.9990983,0.00001379235,0.00009472606,0.00006340598,0.0006117987,0.0001179687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006068595,0.00002354794,0.001897396,0.00001885814,0.0001064927,0.000001268815,0.00004994587,0.0001750576,0.9515191,0.0000857413,0.01668873,0.02882697],"study_design_scores_gemma":[0.001430384,0.0003133111,0.01522226,0.0001150001,0.00005732575,0.00003463781,0.00006186932,0.000383481,0.9380407,0.0005078263,0.04371279,0.0001204109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814448,0.0007295927,0.009338145,0.007453774,0.0007786167,0.0001695489,0.00001807436,0.000002860109,0.00006454981],"genre_scores_gemma":[0.9879252,0.0005125098,0.001248983,0.009189456,0.0006878278,0.0000148354,0.00001016271,0.000007574065,0.0004033981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02870655,"threshold_uncertainty_score":0.2801334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04277358785032104,"score_gpt":0.3668777419741542,"score_spread":0.3241041541238331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}