{"id":"W4406785968","doi":"10.1136/archdischild-2024-327921","title":"Gender affirming hormone therapy for individuals with gender dysphoria aged <26 years: a systematic review and meta-analysis","year":2025,"lang":"en","type":"review","venue":"Archives of Disease in Childhood","topic":"LGBTQ Health, Identity, and Policy","field":"Psychology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"McMaster University","keywords":"Gender dysphoria; Medicine; Meta-analysis; Hormone therapy; MEDLINE; Hormone replacement therapy (female-to-male); Clinical psychology; Gender identity; Psychotherapist; Internal medicine; Testosterone (patch); Social psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01599389,0.002400803,0.01954286,0.006380777,0.0006488842,0.003401329,0.001972629,0.002618086,0.003620208],"category_scores_gemma":[0.03958771,0.001464151,0.03588896,0.005881373,0.0006817079,0.002057906,0.001537424,0.001752335,0.0002397152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003144864,"about_ca_system_score_gemma":0.004829307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006767863,"about_ca_topic_score_gemma":0.01459285,"domain_scores_codex":[0.9894046,0.004975821,0.003272557,0.0008608309,0.001165172,0.0003211361],"domain_scores_gemma":[0.9774392,0.01638088,0.004262885,0.0004483205,0.001231878,0.0002369305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001500163,0.00002808472,0.001831601,0.6595058,0.3194848,0.0001038161,0.00008806085,0.0002781879,0.0001471702,0.0001075245,0.0004675903,0.01645725],"study_design_scores_gemma":[0.0008110199,0.000364617,0.003369337,0.1074531,0.8849347,0.0001382636,0.00007557576,0.0001392754,0.0001117751,0.0001778236,0.002395497,0.0000290591],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002106919,0.9967559,0.0002123407,0.0001499537,0.0001145304,0.0002744564,0.0002187174,0.00001118103,0.0001560333],"genre_scores_gemma":[0.08367734,0.9113979,0.001853727,0.0008977408,0.0002545938,0.001276784,0.000413556,0.00001477812,0.0002135899],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01954286,"threshold_uncertainty_score":0.08458483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07625342241095458,"score_gpt":0.3917047655271225,"score_spread":0.315451343116168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}