{"id":"W4406786620","doi":"10.1007/s13679-024-00601-z","title":"Defining Hyperphagia for Improved Diagnosis and Management of MC4R Pathway–Associated Disease: A Roundtable Summary","year":2025,"lang":"en","type":"review","venue":"Current Obesity Reports","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Disease; Medicine; Etiology; Psychiatry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005245951,0.0004837699,0.001463732,0.0002250404,0.000279322,0.0001566785,0.0002522215,0.0001783062,0.00001124716],"category_scores_gemma":[0.0006773443,0.0004510964,0.0005965465,0.0004271994,0.00008158568,0.0002917265,0.0004244605,0.0002173145,0.000002371679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002109936,"about_ca_system_score_gemma":0.0003419535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008628044,"about_ca_topic_score_gemma":0.000004566753,"domain_scores_codex":[0.9968671,0.0001616791,0.001107785,0.001095153,0.0003493553,0.0004189373],"domain_scores_gemma":[0.9971668,0.0005774156,0.001265098,0.0006911206,0.0001013098,0.0001983154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001473432,0.0008870225,0.002216762,0.09749319,0.0001231377,0.0001273044,0.00001345186,0.000001434623,0.000003777502,0.001975817,0.002221998,0.8949214],"study_design_scores_gemma":[0.0002281953,0.00003614616,0.0007488542,0.03633706,0.00123909,0.00001281617,0.000002002954,0.00002459248,0.0001196721,0.0006977434,0.9600931,0.0004606914],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006037968,0.9944373,0.0001631496,0.00002126003,0.001134022,0.002771524,0.0004513442,0.00009680079,0.0003208288],"genre_scores_gemma":[0.0001788076,0.995655,0.0001183305,0.00001734675,0.00004074047,0.000654518,0.0003890247,0.00003596564,0.002910284],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9578711,"threshold_uncertainty_score":0.9997941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05804424417314444,"score_gpt":0.3373797987955308,"score_spread":0.2793355546223864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}