{"id":"W4406787561","doi":"10.1021/acsptsci.4c00597","title":"Nanoparticle-Mediated mRNA Delivery to Triple-Negative Breast Cancer (TNBC) Patient-Derived Xenograft (PDX) Tumors","year":2025,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; National Research Council Canada; Ottawa Hospital; Institute of Infection and Immunity; University of Ottawa","funders":"National Research Council Canada; Huntsman Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Ottawa Hospital Research Institute; Canadian Institutes of Health Research; University of Ottawa; University of Utah","keywords":"Triple-negative breast cancer; Triple negative; Breast cancer; Cancer research; Cancer; Medicine; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009130626,0.000203634,0.0002023365,0.00007852462,0.00008226424,0.0001677354,0.00007870605,0.0001901231,0.0004110711],"category_scores_gemma":[0.0000853684,0.00006185524,0.000121544,0.00006322673,0.0001184072,0.000113702,0.00008812081,0.0002369656,0.0001267882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002475006,"about_ca_system_score_gemma":0.000170829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008955507,"about_ca_topic_score_gemma":0.001292746,"domain_scores_codex":[0.9999334,0.000009013278,0.000004535814,0.00002014156,0.00002304747,0.000009996505],"domain_scores_gemma":[0.9999719,0.0000065408,0.000007724238,0.000002664407,0.000006130525,0.000005060025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001886852,0.00001118689,0.00005369484,0.00002268288,0.000001492673,0.00003590172,0.00001381021,0.0001311943,0.9983876,0.00006379717,0.00003375947,0.001225877],"study_design_scores_gemma":[0.000005710008,0.0002444041,0.0006170898,0.000002623608,0.000007132414,0.0001486229,0.00001177121,0.001311172,0.996126,0.00001595191,0.001507301,0.000002293405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849594,0.001168337,0.01107014,0.00008304335,0.00004539386,0.00008781337,0.0001853578,0.0001085673,0.002291865],"genre_scores_gemma":[0.9877906,0.0008544811,0.008669169,0.00004585039,0.000007860731,0.00006182531,0.0001774658,0.00002196873,0.002370814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008955507,"threshold_uncertainty_score":0.001795709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009518308823864374,"score_gpt":0.2921283253169329,"score_spread":0.2826100164930685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}