{"id":"W4406789559","doi":"10.1101/2025.01.21.632253","title":"B7-H3 as a Dual Clinically Relevant Checkpoint and Antibody Drug Conjugate Target Expressed Across Adenocarcinoma and Neuroendocrine Prostate Cancers","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Johns Hopkins University; National Cancer Institute; Prostate Cancer Foundation; DOD Prostate Cancer Research Program; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; U.S. Department of Defense","keywords":"Antibody-drug conjugate; Prostate cancer; Conjugate; Dual (grammatical number); Cancer research; Drug; Antibody; Adenocarcinoma; Oncology; Medicine; Internal medicine; Monoclonal antibody; Cancer; Pharmacology; Immunology; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001688801,0.0001824654,0.0002342428,0.0002253308,0.0002002144,0.000394496,0.0001443343,0.0002192024,0.001001201],"category_scores_gemma":[0.00009835708,0.0001120433,0.0002022492,0.0001787678,0.0002262412,0.000151019,0.000181347,0.0003924056,0.000261618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003972955,"about_ca_system_score_gemma":0.0003015993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001681576,"about_ca_topic_score_gemma":0.002040351,"domain_scores_codex":[0.9998046,0.0000225455,0.00001173041,0.00004090771,0.00008218207,0.00003810561],"domain_scores_gemma":[0.9999162,0.00001180809,0.00001808332,0.000008603697,0.00002138734,0.00002392479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001086299,0.00001270793,0.001089244,0.00002390323,0.000007958218,0.00002148328,0.000007856827,0.0001142563,0.9972857,0.00004338185,0.00003376111,0.001251096],"study_design_scores_gemma":[0.00001706925,0.0004448914,0.01372697,0.000004678256,0.00003295775,0.0003594957,0.0000700276,0.001212299,0.9820281,0.00005592295,0.002042333,0.000005127407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933229,0.002005715,0.002847215,0.00008709959,0.00001166284,0.00003487077,0.0004530396,0.00006642764,0.00117114],"genre_scores_gemma":[0.9964006,0.0004558763,0.001657277,0.00005542477,0.000004287192,0.00002189902,0.0004651271,0.00001601538,0.0009234658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001681576,"threshold_uncertainty_score":0.003349364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01650069568599555,"score_gpt":0.3098947213691307,"score_spread":0.2933940256831352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}