{"id":"W4406794616","doi":"10.1021/acs.orglett.4c04675","title":"Enantioselective Decarboxylative Mannich Reactions of α,β-Unsaturated β′-Ketoacids and Isatin Imines: Application in the Synthesis of Spiro[indoline-3,2′-piperidine]-2,4′-diones","year":2025,"lang":"en","type":"article","venue":"Organic Letters","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada; Memorial University of Newfoundland; Canada Foundation for Innovation","keywords":"Chemistry; Indoline; Piperidine; Isatin; Enantioselective synthesis; Mannich reaction; Organic chemistry; Combinatorial chemistry; Medicinal chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002909308,0.0001695464,0.000344941,0.0002461036,0.00006794324,0.00001366641,0.0002476957,0.0001052125,0.00003452013],"category_scores_gemma":[0.0004945729,0.0001281059,0.00008546295,0.001463434,0.0001303788,0.00007804906,0.00004016823,0.0001538518,0.000001894079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008124077,"about_ca_system_score_gemma":0.00004849354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002992103,"about_ca_topic_score_gemma":0.00005296937,"domain_scores_codex":[0.9988148,0.0000733073,0.0004634584,0.0002940286,0.0001914082,0.0001630639],"domain_scores_gemma":[0.9982738,0.0009402856,0.0002853357,0.0003898343,0.00009026925,0.00002042539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004275069,0.0001065033,0.01003354,0.0001301609,0.0001549591,0.000001043638,0.0007239907,0.000006843089,0.9767952,0.0002802299,0.0001206918,0.01160408],"study_design_scores_gemma":[0.0002590849,0.000007932314,0.01700251,0.00009872578,0.0001789968,0.000004104631,0.002788308,0.0002816773,0.9790655,0.00005838221,0.0001404426,0.0001142978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994583,0.0002297668,0.001064713,0.002233051,0.00002048303,0.0001421837,0.00001869247,0.00002099541,0.00168711],"genre_scores_gemma":[0.9994546,0.0001068576,0.0001450053,0.0001275707,0.00003294718,0.00007138197,0.00001197573,0.00001491086,0.00003473456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01148978,"threshold_uncertainty_score":0.5224006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005691318498370975,"score_gpt":0.2215751013980879,"score_spread":0.2158837828997169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}