{"id":"W4406798720","doi":"10.1016/j.devcel.2025.01.001","title":"A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance","year":2025,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Alberta Children's Hospital; University of Toronto; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Brain Tumour Charity; Vetenskapsrådet; Brain Tumour Foundation of Canada; Hospital for Sick Children; Genome British Columbia; Canadian Cancer Society; Swifty Foundation; Ontario Institute for Cancer Research; Ontario Research Foundation; Worldwide Cancer Research; Sontag Foundation; Rally Foundation; Matthew Larson Foundation for Pediatric Brain Tumors; Canadian Institutes of Health Research; Terry Fox Research Institute; Cancer Research Society; Cancer Prevention and Research Institute of Texas; American Cancer Society; Pediatric Brain Tumor Foundation; Stand Up To Cancer; Entertainment Industry Foundation; American Brain Tumor Association; Genome Canada; Cancer Research UK; American Association for Cancer Research","keywords":"Biology; Medulloblastoma; Potassium channel; Genetics; Genetic screen; Channel (broadcasting); Computational biology; Cell biology; Gene; Phenotype; Endocrinology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000251943,0.0006469853,0.0005039114,0.0009041473,0.0004865904,0.0004550738,0.0006433397,0.0006538819,0.006209157],"category_scores_gemma":[0.0003789833,0.0002957176,0.0006473035,0.0003759936,0.0004687591,0.0002151424,0.0004825932,0.0006726069,0.00113744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005289148,"about_ca_system_score_gemma":0.0007274894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002895655,"about_ca_topic_score_gemma":0.006679439,"domain_scores_codex":[0.9996884,0.00003385769,0.00003817108,0.00006066544,0.0001196293,0.00005929071],"domain_scores_gemma":[0.999674,0.0001378637,0.00005444075,0.00002945756,0.00003330837,0.00007095201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000246227,0.00005334812,0.0004754644,0.00002514693,0.00001778314,0.0005800739,0.00002167014,0.0001361389,0.9957566,0.0003039744,0.0002170148,0.00216664],"study_design_scores_gemma":[0.00008810656,0.0004120171,0.004818803,0.00001278849,0.0001261416,0.002546434,0.00007847055,0.001879018,0.9853167,0.0001579318,0.004542034,0.00002154453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745993,0.0006715511,0.01237161,0.0008623989,0.0001758682,0.0002597818,0.004323754,0.0008065072,0.005929183],"genre_scores_gemma":[0.986573,0.0004774207,0.006124929,0.0002100117,0.00001861386,0.00005501572,0.001453144,0.0001892115,0.004898593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006209157,"threshold_uncertainty_score":0.02077174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008748308386628607,"score_gpt":0.2419921681198913,"score_spread":0.2332438597332627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}