{"id":"W4406798720","doi":"10.1016/j.devcel.2025.01.001","title":"A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance","year":2025,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Alberta Children's Hospital; University of Toronto; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Brain Tumour Charity; Vetenskapsrådet; Brain Tumour Foundation of Canada; Hospital for Sick Children; Genome British Columbia; Canadian Cancer Society; Swifty Foundation; Ontario Institute for Cancer Research; Ontario Research Foundation; Worldwide Cancer Research; Sontag Foundation; Rally Foundation; Matthew Larson Foundation for Pediatric Brain Tumors; Canadian Institutes of Health Research; Terry Fox Research Institute; Cancer Research Society; Cancer Prevention and Research Institute of Texas; American Cancer Society; Pediatric Brain Tumor Foundation; Stand Up To Cancer; Entertainment Industry Foundation; American Brain Tumor Association; Genome Canada; Cancer Research UK; American Association for Cancer Research","keywords":"Biology; Medulloblastoma; Potassium channel; Genetics; Genetic screen; Channel (broadcasting); Computational biology; Cell biology; Gene; Phenotype; Endocrinology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001312954,0.0002185332,0.0003321128,0.000262836,0.00007974737,0.00003706256,0.0001197057,0.00008729712,0.0001342077],"category_scores_gemma":[0.0000260888,0.0001930583,0.00009813708,0.0004267726,0.00006709735,0.00005844871,0.0001417378,0.0001176693,0.0001598888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003337754,"about_ca_system_score_gemma":0.0001913054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003888382,"about_ca_topic_score_gemma":0.0005238752,"domain_scores_codex":[0.9985319,0.00003158271,0.0003880207,0.0004073867,0.0002466736,0.000394457],"domain_scores_gemma":[0.9995411,0.00003472972,0.00006236666,0.0001935739,0.0000561087,0.00011211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007769525,0.00422275,0.886483,0.001022106,0.0005557977,0.003026849,0.001848905,0.00005232119,0.04046497,0.0004105813,0.04956358,0.01157218],"study_design_scores_gemma":[0.003501204,0.00005874736,0.8537776,0.0003355792,0.00007357926,0.00004512125,0.0006423502,0.0001184042,0.1378713,0.0003417948,0.003023483,0.000210754],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982692,0.0005150434,0.0002293287,0.00116335,0.0003074538,0.0005907815,0.00001857337,0.00004937547,0.01443409],"genre_scores_gemma":[0.9934353,0.00009370572,0.002532011,0.0006335858,0.00002374409,0.0001407182,0.00006113411,0.00001698923,0.003062812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09740637,"threshold_uncertainty_score":0.7872687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008748308386628607,"score_gpt":0.2419921681198913,"score_spread":0.2332438597332627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}