{"id":"W4406801161","doi":"10.1007/s40262-025-01476-6","title":"Population Pharmacokinetic Modelling of Apixaban in End-Stage Kidney Disease Patients with Atrial Fibrillation Receiving Haemodialysis","year":2025,"lang":"en","type":"article","venue":"Clinical Pharmacokinetics","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"","keywords":"Apixaban; Atrial fibrillation; Medicine; End stage renal disease; Cardiology; Internal medicine; Population pharmacokinetics; Stage (stratigraphy); Pharmacokinetics; Kidney disease; End-stage kidney disease; Population; Disease; Warfarin; Rivaroxaban","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005627307,0.0002384441,0.0006792771,0.0004302588,0.00005542714,0.0000217869,0.0001116668,0.0001045722,0.0003221184],"category_scores_gemma":[0.0006336836,0.0002124011,0.0003847482,0.0008160991,0.00008972479,0.0001467003,0.00008735222,0.0002403086,0.000006380346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007954904,"about_ca_system_score_gemma":0.0001179398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003587775,"about_ca_topic_score_gemma":0.000002597956,"domain_scores_codex":[0.9972721,0.000201802,0.00135494,0.0004448529,0.0004644662,0.0002618377],"domain_scores_gemma":[0.9982844,0.0005174118,0.0004047219,0.0003096642,0.0002112482,0.0002725378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002662541,0.00003769084,0.8396675,0.0002174945,0.0001779655,0.000004187094,0.00002125146,0.1422294,0.00002470355,0.00009905349,0.0002316847,0.01462649],"study_design_scores_gemma":[0.01027481,0.0001032599,0.7641726,0.000233316,0.001144172,6.291976e-8,0.000005830018,0.2159198,0.0000582776,0.0001471214,0.00775107,0.0001897248],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890435,0.0001749787,0.006839505,0.001266089,0.0007971089,0.001169971,0.00005281533,0.00006732195,0.0005887434],"genre_scores_gemma":[0.9952611,0.000382291,0.001650431,0.00037127,0.0008720789,0.000001519336,0.0005740559,0.000029805,0.0008574462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07549492,"threshold_uncertainty_score":0.8661466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08437348808330872,"score_gpt":0.3959750635750126,"score_spread":0.3116015754917039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}