{"id":"W4406801649","doi":"10.3390/cancers17030388","title":"Denosumab vs. Zoledronic Acid for Metastatic Bone Disease: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Trials","year":2025,"lang":"en","type":"review","venue":"Cancers","topic":"Bone health and treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"","keywords":"Denosumab; Medicine; Zoledronic acid; Randomized controlled trial; Meta-analysis; Oncology; Internal medicine; Adverse effect; Quality of life (healthcare); Bone pain; Breast cancer; Pathologic fracture; Cancer; Surgery; Osteoporosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01379234,0.002512511,0.01957309,0.006053536,0.0006114464,0.002826254,0.002245783,0.001991566,0.00431109],"category_scores_gemma":[0.02747041,0.001231314,0.03399922,0.007004638,0.0006341321,0.001602547,0.001369338,0.001789755,0.0002809584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002874303,"about_ca_system_score_gemma":0.004028468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006912278,"about_ca_topic_score_gemma":0.01345045,"domain_scores_codex":[0.9892635,0.005576096,0.002688291,0.001103752,0.001047093,0.0003212496],"domain_scores_gemma":[0.9852673,0.01039613,0.002752593,0.0003595485,0.0009842659,0.0002401971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003380019,0.00003560971,0.002662467,0.4183875,0.5598643,0.00008671396,0.00005884732,0.0006396028,0.0001735452,0.0001901374,0.0007348157,0.01378639],"study_design_scores_gemma":[0.001648788,0.0002727933,0.002627993,0.02825845,0.9648449,0.00006832137,0.00003829939,0.0002256947,0.00008757115,0.0002866002,0.001617452,0.00002310999],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003764316,0.9943223,0.0004257443,0.0001862168,0.0001151565,0.0003530733,0.0005891225,0.00002257621,0.0002214775],"genre_scores_gemma":[0.1659257,0.8263476,0.002921931,0.001167181,0.0002561164,0.001743314,0.001299003,0.00003866938,0.0003004662],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01957309,"threshold_uncertainty_score":0.07294172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1380567559953742,"score_gpt":0.4437560953395993,"score_spread":0.3056993393442251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}