{"id":"W4406802705","doi":"10.2147/ott.s496228","title":"Dynamic Coupling of MAPK Signaling to the Guanine Nucleotide Exchange Factor GEF-H1","year":2025,"lang":"en","type":"review","venue":"OncoTargets and Therapy","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto","keywords":"Guanine nucleotide exchange factor; Guanine; MAPK/ERK pathway; Cell biology; Coupling (piping); Nucleotide; Factor (programming language); Chemistry; Signal transduction; Computational biology; Bioinformatics; Biology; Medicine; Computer science; Biochemistry; Materials science; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001045314,0.0003063412,0.0002414456,0.0001877835,0.0001175206,0.0003289328,0.0002095526,0.0002568169,0.001168901],"category_scores_gemma":[0.00008158807,0.00006598869,0.0001575581,0.0001472364,0.0001059607,0.0002683869,0.000161392,0.0003735299,0.0005259258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003289777,"about_ca_system_score_gemma":0.0002135688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002035756,"about_ca_topic_score_gemma":0.0003319511,"domain_scores_codex":[0.9999391,0.000009262942,0.000005834591,0.00001543913,0.00001947483,0.00001091723],"domain_scores_gemma":[0.9999746,0.000005213637,0.000006619478,0.000001284087,0.000008142246,0.000004122761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003669006,0.0000510466,0.0008131365,0.006164744,0.0001151318,0.0009285815,0.0001172843,0.00110782,0.8023197,0.004578281,0.00630902,0.1771283],"study_design_scores_gemma":[0.00006474849,0.0005722734,0.006680179,0.0002957912,0.0001871577,0.00301021,0.0001476269,0.001387748,0.5074458,0.001925415,0.4782331,0.00004998682],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1513421,0.8169567,0.007570406,0.001517649,0.001231115,0.00005839165,0.0006224628,0.0003590279,0.02034214],"genre_scores_gemma":[0.5276274,0.4549259,0.003027997,0.0005524016,0.0006552543,0.00006990199,0.0007814849,0.00004008418,0.01231958],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001168901,"threshold_uncertainty_score":0.003910363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02186933261750735,"score_gpt":0.3088443212434147,"score_spread":0.2869749886259073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}