{"id":"W4406805610","doi":"10.1038/s43018-024-00900-3","title":"TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states","year":2025,"lang":"en","type":"article","venue":"Nature Cancer","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; National Human Genome Research Institute; Max-Planck-Gesellschaft","keywords":"Epigenetics; Cancer; Biology; Genetics; Epigenesis; DNA methylation; Evolutionary biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001646236,0.0003075579,0.0003879554,0.00008155277,0.0002485314,0.00002740535,0.0003531926,0.0005417782,0.002105434],"category_scores_gemma":[0.0001168785,0.0002474856,0.0001419632,0.0001820743,0.0002497396,0.00008797942,0.0001771554,0.0006874361,0.00008809612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004869475,"about_ca_system_score_gemma":0.0004878727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008769624,"about_ca_topic_score_gemma":0.005688828,"domain_scores_codex":[0.9983191,0.0002381056,0.0003736419,0.0005292405,0.00005819354,0.000481684],"domain_scores_gemma":[0.9992613,0.0001722787,0.00009919101,0.0002916296,0.0001551603,0.00002044674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002748796,0.0003145836,0.1348688,0.0002079928,0.001087057,0.00001478777,0.000962975,0.00001998771,0.7857903,0.0002255079,0.02455106,0.04920819],"study_design_scores_gemma":[0.001155853,0.00006316762,0.08097719,0.0001210706,0.00007076,0.0000113696,0.0001577069,0.000002044184,0.789547,0.0001561471,0.1274645,0.0002732144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9195728,0.07484814,0.0001254089,0.0005719487,0.003274921,0.0003415925,0.0002655443,0.00008493129,0.0009146626],"genre_scores_gemma":[0.9849787,0.001795438,0.00005309118,0.001293143,0.00004929041,0.0001749433,0.00007966437,0.00001896859,0.01155681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1029134,"threshold_uncertainty_score":0.9999977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01335833808222487,"score_gpt":0.3243577507310907,"score_spread":0.3109994126488659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}