{"id":"W4406805641","doi":"10.1161/circgen.123.004412","title":"Atrial Fibrillation Related Titin Truncation Is Associated With Atrial Myopathy in Patient-Derived Induced Pluripotent Stem Cell Disease Models","year":2025,"lang":"en","type":"article","venue":"Circulation Genomic and Precision Medicine","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; BC Children's Hospital; Population Health Research Institute; York University; University of British Columbia","funders":"","keywords":"Induced pluripotent stem cell; Sarcomere; Titin; Contractility; Atrial fibrillation; Internal medicine; Myocyte; Myopathy; Cardiology; Stem cell; Biology; Medicine; Cell biology; Gene; Genetics; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005045305,0.0002364432,0.0005775923,0.0003899952,0.0001585827,0.00001756899,0.00004407466,0.0001753162,0.00003466548],"category_scores_gemma":[0.0001989127,0.0001900758,0.0001499746,0.0005198324,0.00007919957,0.0001317831,0.00005020972,0.000190703,0.000004367232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002922019,"about_ca_system_score_gemma":0.0001975805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005042758,"about_ca_topic_score_gemma":0.000006758167,"domain_scores_codex":[0.9979751,0.0001865301,0.0007354394,0.0004864167,0.0004062455,0.0002102832],"domain_scores_gemma":[0.9987725,0.0002868407,0.0002865337,0.000273362,0.0002291479,0.0001516309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02089031,0.0001873244,0.30984,0.0005251268,0.001219593,0.0002095296,0.03174042,0.05752865,0.08903426,0.0008375793,0.001348499,0.4866388],"study_design_scores_gemma":[0.02486307,0.0007314314,0.9033258,0.001838357,0.001466332,0.00002355769,0.002133496,0.06094093,0.0003834131,0.003167693,0.0006744058,0.0004515497],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891019,0.005716668,0.001426707,0.001120185,0.0005157912,0.001313318,0.00001781116,0.00005832182,0.0007292471],"genre_scores_gemma":[0.998415,0.0006642858,0.00003896224,0.000202933,0.000264634,0.000008282243,0.0002068657,0.00002078378,0.0001782809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5934858,"threshold_uncertainty_score":0.7751065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0220979599901846,"score_gpt":0.2490236366129315,"score_spread":0.2269256766227469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}