{"id":"W4406808851","doi":"10.3389/fmed.2025.1493832","title":"A conceptual model and practical guidance for the development, administration, and evaluation of individualized therapies","year":2025,"lang":"en","type":"article","venue":"Frontiers in Medicine","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Toronto Public Health; Hospital for Sick Children; Public Health Ontario; University of Toronto","funders":"","keywords":"Administration (probate law); Conceptual model; Management science; Computer science; Medicine; Process management; Engineering; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03912242,0.001697524,0.0008536295,0.003145395,0.004945718,0.01435014,0.006267217,0.01675108,0.011269],"category_scores_gemma":[0.02433659,0.001153951,0.001971494,0.002221327,0.02946949,0.01411481,0.008429418,0.01006967,0.003666318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01462399,"about_ca_system_score_gemma":0.02967265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00817721,"about_ca_topic_score_gemma":0.007833921,"domain_scores_codex":[0.9675271,0.02176417,0.002093579,0.002283337,0.005133337,0.001198449],"domain_scores_gemma":[0.9761012,0.01529415,0.001633582,0.001859717,0.003383387,0.001727926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000009126209,0.00003725616,0.0001395228,0.0001491391,0.000004298354,0.0001234108,0.001879296,0.0007759416,0.0001133281,0.9872047,0.003242523,0.006321453],"study_design_scores_gemma":[0.00008572659,0.0001291088,0.000276652,0.001438109,0.00002407365,0.0005488258,0.003150821,0.004222997,0.0003993257,0.7859412,0.2037198,0.00006337428],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.005305588,0.004341712,0.569948,0.1882869,0.0008001784,0.003389742,0.000482124,0.0005211477,0.2269246],"genre_scores_gemma":[0.1335646,0.004146763,0.8123833,0.01910754,0.0002780566,0.008386643,0.0003442464,0.0001734116,0.02161541],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.03912242,"threshold_uncertainty_score":0.2069016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3896722897365892,"score_gpt":0.4884695081173234,"score_spread":0.09879721838073419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}