{"id":"W4406809476","doi":"10.21037/tcr-24-1711","title":"On the precipice of a new generation of biomarkers for immunotherapy in small cell lung cancer","year":2025,"lang":"en","type":"letter","venue":"Translational Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen Elizabeth II Health Sciences Centre","funders":"","keywords":"Immunotherapy; Lung cancer; Medicine; Cancer; Cancer immunotherapy; Oncology; Cancer research; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001301722,0.0002434705,0.0005635801,0.0007624829,0.0001123245,0.00001758128,0.0003904182,0.0003303607,0.0006220244],"category_scores_gemma":[0.000146864,0.0001771023,0.0002344969,0.0009203055,0.0002715462,0.00004082949,0.00003214883,0.001459121,8.043535e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006233356,"about_ca_system_score_gemma":0.005490312,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01041097,"about_ca_topic_score_gemma":0.002872854,"domain_scores_codex":[0.9966627,0.0003182618,0.0005707658,0.000479381,0.001435095,0.0005337996],"domain_scores_gemma":[0.9961457,0.002255514,0.0001431077,0.0004339966,0.0009754136,0.00004628489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002957966,0.00009002031,0.001801224,0.004034017,0.0008803392,0.000005018423,0.001211379,0.0004232164,0.009960026,0.0002922179,0.9723285,0.00601604],"study_design_scores_gemma":[0.02099381,0.001948465,0.01391747,0.01177684,0.0005872378,0.000001931586,0.0001819987,0.008582942,0.1036905,0.004292548,0.8330893,0.000936925],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01641834,0.03414489,0.0004849867,0.9376268,0.0002939894,0.006886311,0.001188804,0.000013765,0.002942132],"genre_scores_gemma":[0.2621624,0.09889369,0.006746512,0.3560607,0.02764796,0.05075677,0.004540449,0.001048797,0.1921427],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.581566,"threshold_uncertainty_score":0.9961788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.185177797886755,"score_gpt":0.4655473992923152,"score_spread":0.2803696014055602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}