{"id":"W4406814170","doi":"10.1111/liv.16240","title":"Precision in Liver Diagnosis: Varied Accuracy Across Subgroups and the Need for Variable Thresholds in Diagnosis of <scp>MASLD</scp>","year":2025,"lang":"en","type":"article","venue":"Liver International","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Medical Sciences, Newcastle University; Intercept Pharmaceuticals; Assistance publique-Hôpitaux de Paris; Sorbonne Université; Universiteit Antwerpen; Astellas Pharma; Linköpings Universitet; Swedish Orphan Biovitrum; Novo Nordisk; Università degli Studi di Torino; Institut de Cardiométabolisme et Nutrition; Eisai; Ipsen; CSL Behring; Fonds Wetenschappelijk Onderzoek; Shionogi; Minerva Foundation; Universiteit van Amsterdam; Newcastle University; European Commission; AstraZeneca; Genentech; National Institute for Health and Care Research; Vlaamse regering; University of Oxford; University of Cambridge; Cancer Research UK; Coherus Biosciences; Universität des Saarlandes; Amsterdam University Medical Centers; European Federation of Pharmaceutical Industries and Associations; Pfizer; Università degli Studi di Milano; Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu; Sanofi; Julius Clinical; Canadian Institute for Theoretical Astrophysics; Helsingin Yliopisto; Bristol-Myers Squibb; Universitätsmedizin der Johannes Gutenberg-Universität Mainz; Eli Lilly and Company; Allergan; Alexion Pharmaceuticals; Universidad de Sevilla; Gilead Sciences; NGM Biopharmaceuticals; Inventiva Pharma; Novartis Pharmaceuticals Corporation; Novartis Pharma","keywords":"Receiver operating characteristic; Transient elastography; Medicine; Internal medicine; Liver fibrosis; Fibrosis; Gastroenterology; Prospective cohort study; Body mass index; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05678026,0.0007045994,0.001543961,0.001879214,0.000508135,0.001870959,0.001006161,0.001465116,0.0005441738],"category_scores_gemma":[0.07518118,0.0003864198,0.001655691,0.00150335,0.001018386,0.001232657,0.001455021,0.000762848,0.0002221745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007151834,"about_ca_system_score_gemma":0.0006237276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001109446,"about_ca_topic_score_gemma":0.001242701,"domain_scores_codex":[0.9630082,0.02282062,0.003959662,0.005406521,0.004172866,0.0006321768],"domain_scores_gemma":[0.8865668,0.08274034,0.0162136,0.009824175,0.003889698,0.0007653046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002890753,0.0000436796,0.9600194,0.0002428358,0.001306736,0.00008369763,0.0003458286,0.001538274,0.001868478,0.0001438538,0.0001789015,0.03133767],"study_design_scores_gemma":[0.0001107232,0.001581807,0.9827405,0.0001655491,0.001226909,0.000835597,0.0002535953,0.007200806,0.003834777,0.001288137,0.0007113531,0.00005031078],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793782,0.008962306,0.009147007,0.0005462264,0.00005120777,0.00006771601,0.0004348362,0.00009301171,0.00131938],"genre_scores_gemma":[0.9974796,0.0001402143,0.002002844,0.00009779644,0.00002980604,0.00002194819,0.0001747855,0.00001063566,0.00004230701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05678026,"threshold_uncertainty_score":0.3002864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01743503404634348,"score_gpt":0.3032174790651179,"score_spread":0.2857824450187744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}