{"id":"W4406814170","doi":"10.1111/liv.16240","title":"Precision in Liver Diagnosis: Varied Accuracy Across Subgroups and the Need for Variable Thresholds in Diagnosis of <scp>MASLD</scp>","year":2025,"lang":"en","type":"article","venue":"Liver International","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Medical Sciences, Newcastle University; Intercept Pharmaceuticals; Assistance publique-Hôpitaux de Paris; Sorbonne Université; Universiteit Antwerpen; Astellas Pharma; Linköpings Universitet; Swedish Orphan Biovitrum; Novo Nordisk; Università degli Studi di Torino; Institut de Cardiométabolisme et Nutrition; Eisai; Ipsen; CSL Behring; Fonds Wetenschappelijk Onderzoek; Shionogi; Minerva Foundation; Universiteit van Amsterdam; Newcastle University; European Commission; AstraZeneca; Genentech; National Institute for Health and Care Research; Vlaamse regering; University of Oxford; University of Cambridge; Cancer Research UK; Coherus Biosciences; Universität des Saarlandes; Amsterdam University Medical Centers; European Federation of Pharmaceutical Industries and Associations; Pfizer; Università degli Studi di Milano; Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu; Sanofi; Julius Clinical; Canadian Institute for Theoretical Astrophysics; Helsingin Yliopisto; Bristol-Myers Squibb; Universitätsmedizin der Johannes Gutenberg-Universität Mainz; Eli Lilly and Company; Allergan; Alexion Pharmaceuticals; Universidad de Sevilla; Gilead Sciences; NGM Biopharmaceuticals; Inventiva Pharma; Novartis Pharmaceuticals Corporation; Novartis Pharma","keywords":"Receiver operating characteristic; Transient elastography; Medicine; Internal medicine; Liver fibrosis; Fibrosis; Gastroenterology; Prospective cohort study; Body mass index; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004603165,0.0001816991,0.0003683547,0.0002062146,0.00006114181,0.00006098874,0.0002326501,0.0001117795,0.00009728182],"category_scores_gemma":[0.001256872,0.0001313279,0.0001342807,0.0002930659,0.0001368467,0.0002256599,0.000205308,0.0001425835,0.000005131575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001647717,"about_ca_system_score_gemma":0.00009383877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001271101,"about_ca_topic_score_gemma":0.0002908403,"domain_scores_codex":[0.9985808,0.00006739493,0.0004417928,0.0003562625,0.0003087383,0.000245061],"domain_scores_gemma":[0.9949117,0.004463679,0.0001295196,0.0002381542,0.0001942465,0.00006266557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007225918,0.001524067,0.9638581,0.0001262446,0.0003530072,0.00003245588,0.002025525,0.0000606149,0.00001311602,0.02244511,0.003646848,0.005192316],"study_design_scores_gemma":[0.01335834,0.0001477114,0.9701084,0.0008179507,0.0002127589,0.000004007384,0.0004972803,0.003807257,0.001568449,0.00386764,0.005545438,0.00006472415],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906112,0.003645943,0.0001709989,0.001485643,0.000339166,0.001537439,0.0002175418,0.00001704956,0.001975025],"genre_scores_gemma":[0.9926457,0.003619831,0.0005028537,0.0007851167,0.00007147238,0.001849762,0.00009645917,0.00001369798,0.0004150524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01857747,"threshold_uncertainty_score":0.5355394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01743503404634348,"score_gpt":0.3032174790651179,"score_spread":0.2857824450187744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}