{"id":"W4406818932","doi":"10.1101/2025.01.20.633998","title":"Hyperacute Response Proteins (HARPs) synthesized on γ-tubulin-FTO-MARK4 translation microdomains upon exposure to stress, regulate stress response in cancer","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; University of Alberta","funders":"","keywords":"Stress (linguistics); Translation (biology); Fight-or-flight response; Chemistry; Cancer; Tubulin; Microtubule; Biophysics; Cell biology; Cancer research; Biology; Medicine; Biochemistry; Internal medicine; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009613266,0.0002403363,0.0001952742,0.000286754,0.0003066012,0.0003093973,0.000105984,0.0002153681,0.0009786722],"category_scores_gemma":[0.0001153189,0.0001117724,0.0003217775,0.0002904565,0.0001481888,0.0001998829,0.0002078135,0.0002884857,0.0003947323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003774668,"about_ca_system_score_gemma":0.0002153466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009553304,"about_ca_topic_score_gemma":0.001556227,"domain_scores_codex":[0.9999185,0.000006138358,0.000006682011,0.00002755601,0.00002146428,0.00001969418],"domain_scores_gemma":[0.999929,0.000005603315,0.00002984466,0.000005686162,0.00001602334,0.00001395638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001191526,0.00000608379,0.0019962,0.00005100545,0.00001261674,0.00004524969,0.0000202701,0.00006338838,0.9959677,0.00003979448,0.00008710544,0.001591368],"study_design_scores_gemma":[0.000009241541,0.0002107833,0.1340554,0.00001729695,0.00006027909,0.0005789981,0.000166622,0.001278135,0.8563287,0.0001516415,0.007127455,0.00001540566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903527,0.003388818,0.003067213,0.00009922755,0.0000279508,0.00002236296,0.002115896,0.000101254,0.0008244721],"genre_scores_gemma":[0.9879749,0.001791638,0.003156402,0.000101767,0.00001243792,0.00004712296,0.003876466,0.0000311697,0.003008125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009786722,"threshold_uncertainty_score":0.003274024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01144785653357632,"score_gpt":0.2559803575241223,"score_spread":0.244532500990546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}