{"id":"W4406842956","doi":"10.1002/alz.14492","title":"A multi‐cohort study of longitudinal and cross‐sectional Alzheimer's disease biomarkers in cognitively unimpaired older adults","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Lewy Body Dementia Association; H. Lundbeck A/S; Servier; Eisai; GHR Foundation; IXICO; Fred A. And Barbara M. Erb Family Foundation; Pfizer; Biogen; BioClinica; University of Southern California; Northern California Institute for Research and Education; Massachusetts General Hospital; U.S. Department of Defense; BrightFocus Foundation; Eli Lilly and Company; Bristol-Myers Squibb; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Fondation Philippe Chatrier; Meso Scale Diagnostics; Alzheimer's Association; Brigham and Women's Hospital","keywords":"Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Magnetic resonance imaging; Cognition; Temporal lobe; Neurodegeneration; Atrophy; Psychology; Generalizability theory; Alzheimer's disease; Cohort; Neuroscience; Positron emission tomography; Disease; Medicine; Cognitive decline; Internal medicine; Dementia; Cognitive impairment; Developmental psychology; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002531874,0.0005982926,0.0006216321,0.0006707343,0.001169669,0.0007327107,0.0007068046,0.0007543586,0.00102001],"category_scores_gemma":[0.002951353,0.0004586168,0.0007830327,0.001218339,0.0003430371,0.0006646443,0.0007645965,0.0006849004,0.0004059066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004840454,"about_ca_system_score_gemma":0.0005139158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01245261,"about_ca_topic_score_gemma":0.01809735,"domain_scores_codex":[0.9988785,0.0003595508,0.0001565894,0.0003572314,0.0001246783,0.0001234104],"domain_scores_gemma":[0.9977628,0.0002578345,0.0005352452,0.0007459845,0.000297351,0.0004008142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007634922,0.0001934294,0.996213,0.00002605377,0.0004111077,0.0001559129,0.0002841255,0.00003747234,0.0005569506,0.00003605797,0.0001836534,0.0011389],"study_design_scores_gemma":[0.00004775101,0.0002475379,0.9987996,0.000009996289,0.000137639,0.000186341,0.0001708475,0.0001266705,0.00006635454,0.00003308847,0.0001687128,0.00000555218],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988833,0.0001722963,0.0002032691,0.00001801983,0.00000733101,0.00003434601,0.000592075,0.000003215274,0.00008609433],"genre_scores_gemma":[0.9988254,0.00006104077,0.0002532428,0.00004535153,0.000007859628,0.00005930917,0.0006339562,0.000002421493,0.0001115051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01245261,"threshold_uncertainty_score":0.02476025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02787272104354618,"score_gpt":0.3415273424016181,"score_spread":0.3136546213580719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}