{"id":"W4406844310","doi":"10.3390/ph18020164","title":"Prolonged Impact of Bisphosphonates and Glucocorticoids on Bone Mechanical Properties","year":2025,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Bone health and osteoporosis research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Réseau de Recherche en Santé Buccodentaire et Osseuse","keywords":"Thermogravimetric analysis; Zoledronic acid; Pyridinoline; Medicine; Apatite; Ultimate tensile strength; Differential scanning calorimetry; Fourier transform infrared spectroscopy; Dentistry; Internal medicine; Chemistry; Alkaline phosphatase; Materials science; Mineralogy; Osteocalcin; Composite material; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004533358,0.0001382975,0.0004161239,0.0001526822,0.00005985071,0.00001322503,0.00005776071,0.00009588192,0.0001925466],"category_scores_gemma":[0.000716975,0.00008974822,0.0001007663,0.0002939447,0.0001827683,0.00003640463,0.00007458292,0.0003540172,0.00001957983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007070395,"about_ca_system_score_gemma":0.0003472805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007784348,"about_ca_topic_score_gemma":0.000003200202,"domain_scores_codex":[0.9986298,0.00007869103,0.0003649771,0.0002460428,0.0002939382,0.0003865552],"domain_scores_gemma":[0.9990528,0.0002129478,0.00003985848,0.0002051625,0.0001485914,0.0003406558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00962425,0.001173193,0.03216671,0.001503487,0.0002449562,0.00004504354,0.0002000906,0.000002322384,0.8519322,0.002149385,0.002026041,0.0989323],"study_design_scores_gemma":[0.004518833,0.001166801,0.1053357,0.0004395179,0.0001367858,0.00003740795,0.00005085345,0.00211257,0.884095,0.0004344125,0.001547687,0.0001244622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889137,0.004954018,0.000008096716,0.004185838,0.00005567773,0.0008421159,0.000008813471,0.00004412963,0.0009876048],"genre_scores_gemma":[0.9973806,0.0008608817,0.000119962,0.001151398,0.00002313321,0.00006509739,0.000003370417,0.00001286,0.0003827379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09880783,"threshold_uncertainty_score":0.3659826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06580306309451638,"score_gpt":0.4408343281491942,"score_spread":0.3750312650546778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}