{"id":"W4406854667","doi":"10.1182/blood.2024025355","title":"Integrative genomic analysis of DLBCL identifies immune environments associated with bispecific antibody response","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Spinal Cord Injury BC; BC Cancer Agency","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"Diffuse large B-cell lymphoma; Immune system; Germinal center; CD19; Immunotherapy; Chimeric antigen receptor; B cell; T cell; Cancer research; Lymphoma; CD20; Biology; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006955782,0.0001565837,0.0005998751,0.0008836432,0.00006108574,0.00002182893,0.0001605492,0.00008677704,0.0009879472],"category_scores_gemma":[0.0002441021,0.0001196363,0.0002204625,0.001614719,0.0002208695,0.00004018406,0.00007499688,0.0002206103,0.00001591109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001410426,"about_ca_system_score_gemma":0.0001348657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008572335,"about_ca_topic_score_gemma":0.00005926335,"domain_scores_codex":[0.998475,0.0002692227,0.0003414546,0.0002964731,0.0003842665,0.0002335907],"domain_scores_gemma":[0.9988574,0.0003453571,0.000131056,0.0005321286,0.00007896298,0.00005502711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002504886,0.001224382,0.09892147,0.00001201312,0.01008516,0.00004949712,0.0005685263,0.000007043159,0.886305,0.00001775706,0.00003704608,0.0002672421],"study_design_scores_gemma":[0.003791127,0.0003138241,0.7470417,0.0001162167,0.002838142,0.000001940812,0.0005074039,0.0000586369,0.244855,0.00001348598,0.0003794376,0.00008304028],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961172,0.0007436465,0.0001168506,0.0001497095,0.00003102269,0.0003524103,0.00004221781,0.00002205697,0.002424858],"genre_scores_gemma":[0.9545522,0.0002165952,0.00004759072,0.00002739039,0.000009151558,0.00001548705,0.0001500715,0.00001772429,0.04496383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6481202,"threshold_uncertainty_score":0.9999253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0136909294797624,"score_gpt":0.3065875653718829,"score_spread":0.2928966358921205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}