{"id":"W4406854667","doi":"10.1182/blood.2024025355","title":"Integrative genomic analysis of DLBCL identifies immune environments associated with bispecific antibody response","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Spinal Cord Injury BC; BC Cancer Agency","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"Diffuse large B-cell lymphoma; Immune system; Germinal center; CD19; Immunotherapy; Chimeric antigen receptor; B cell; T cell; Cancer research; Lymphoma; CD20; Biology; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002753563,0.0002079499,0.0003659324,0.001235217,0.0001579946,0.0004295894,0.0001416309,0.000144208,0.0008009135],"category_scores_gemma":[0.0004137066,0.0001063464,0.000290276,0.0008692428,0.0001892673,0.0001148971,0.000470517,0.0002418571,0.0001312757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002653651,"about_ca_system_score_gemma":0.0001546219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009788545,"about_ca_topic_score_gemma":0.001592206,"domain_scores_codex":[0.999746,0.0000406344,0.00001480877,0.0001039115,0.00004692279,0.00004765431],"domain_scores_gemma":[0.9997845,0.00005441584,0.00008130243,0.00002266954,0.0000244334,0.00003273432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001058619,0.0001230012,0.3084839,0.00009044044,0.0003224088,0.0001715584,0.0002125777,0.001264072,0.6660628,0.0001694426,0.0001818983,0.02185913],"study_design_scores_gemma":[0.00001861613,0.0002221043,0.9723973,0.000005368947,0.0001489814,0.0003548499,0.0001609876,0.004287362,0.02151351,0.000181681,0.0007013355,0.000007914762],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972736,0.0001909261,0.001548041,0.00001546591,0.000001498515,0.00001275365,0.0007206465,0.00002553825,0.000211515],"genre_scores_gemma":[0.9973097,0.00005149783,0.001160087,0.0000248815,0.000002661372,0.00001752323,0.001312606,0.00001032785,0.0001108185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001235217,"threshold_uncertainty_score":0.002679288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0136909294797624,"score_gpt":0.3065875653718829,"score_spread":0.2928966358921205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}