{"id":"W4406854676","doi":"10.1200/jco.24.00848","title":"Elective Discontinuation of Larotrectinib in Pediatric Patients With TRK Fusion Sarcomas and Related Mesenchymal Tumors","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bayer (Canada); Centre Hospitalier Universitaire Sainte-Justine; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; Loxo Oncology; Bayer HealthCare; Jazz Pharmaceuticals; Eisai; Genentech; Y-mAbs Therapeutics; Royal Marsden NHS Foundation Trust; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; National Institute for Health and Care Research; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Medicine; Discontinuation; Trk receptor; Sarcoma; Internal medicine; Adverse effect; Surgery; Oncology; Pathology; Receptor; Neurotrophin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001315538,0.0001796585,0.0007313465,0.000178835,0.0001886116,0.0003450447,0.000183509,0.0002054254,0.0004866945],"category_scores_gemma":[0.001421796,0.0001154027,0.0007596677,0.0003471551,0.0002311978,0.0002540404,0.0001845687,0.0005856385,0.00005271774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007577495,"about_ca_system_score_gemma":0.000942854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008881527,"about_ca_topic_score_gemma":0.003054552,"domain_scores_codex":[0.9993879,0.0002511287,0.0000583288,0.00008199098,0.0001165754,0.0001040281],"domain_scores_gemma":[0.9985246,0.0004686653,0.0006715643,0.00007401461,0.00006927495,0.0001918576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"case_report","study_design_scores_codex":[0.04256083,0.0009257584,0.8214177,0.0004154657,0.0009660014,0.001641448,0.0002536021,0.001854892,0.01100833,0.0004456724,0.002325637,0.1161847],"study_design_scores_gemma":[0.005081272,0.04715944,0.9258152,0.00009542602,0.0009048728,0.004044405,0.0002647855,0.002182893,0.005808462,0.000354395,0.008263272,0.00002559381],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971186,0.001552892,0.0002376168,0.00007767328,0.000009187423,0.00006522557,0.0003203282,0.000006814359,0.0006116788],"genre_scores_gemma":[0.9978441,0.0007524447,0.0003087819,0.0001554523,0.00002377025,0.00007112686,0.0007182986,0.000003929686,0.000122194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001315538,"threshold_uncertainty_score":0.006957293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03027776070074528,"score_gpt":0.3971230990387378,"score_spread":0.3668453383379925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}