{"id":"W4406854679","doi":"10.1200/po.24.00199","title":"Clinical Activity of Mitogen-Activated Protein Kinase Inhibitors in Patients With MAP2K1 (MEK1)-Mutated Metastatic Cancers","year":2025,"lang":"en","type":"review","venue":"JCO Precision Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University; Jewish General Hospital","funders":"National Cancer Institute; Conquer Cancer Foundation","keywords":"MAPK/ERK pathway; Mutant; Cancer; Mutation; Cancer research; Medicine; Kinase; Protein kinase A; Internal medicine; Oncology; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007562436,0.0007675491,0.006149663,0.003189997,0.0002238644,0.001399702,0.0007920733,0.0008766029,0.001243326],"category_scores_gemma":[0.01698634,0.0005813406,0.01135852,0.004710071,0.0003704533,0.0007572326,0.0005539744,0.0008681539,0.0001315904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001138202,"about_ca_system_score_gemma":0.001031902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002840255,"about_ca_topic_score_gemma":0.006238373,"domain_scores_codex":[0.9945053,0.002163317,0.001840166,0.0007583816,0.0006049674,0.0001278132],"domain_scores_gemma":[0.9850603,0.009870066,0.003681617,0.0003134661,0.0009206228,0.0001538973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007360504,0.00007144244,0.05019973,0.3710364,0.4994627,0.0001808522,0.0001449034,0.001047304,0.001107525,0.0002447771,0.002139128,0.06700462],"study_design_scores_gemma":[0.002028497,0.001007296,0.0820253,0.04360652,0.8603919,0.0005567376,0.0001465552,0.0005129235,0.0007567166,0.000521886,0.008388813,0.00005689945],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01082036,0.9875976,0.0001449103,0.0001944807,0.0000568941,0.00005688152,0.000769594,0.000006915525,0.0003523186],"genre_scores_gemma":[0.4419067,0.5539083,0.0008711693,0.001064306,0.0003753007,0.0002690075,0.001416833,0.00001740517,0.0001709457],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007562436,"threshold_uncertainty_score":0.03999442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03349304482601181,"score_gpt":0.3678672657524481,"score_spread":0.3343742209264363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}