{"id":"W4406863621","doi":"10.1146/annurev-med-052423-122001","title":"New Oral Selective Estrogen Receptor Degraders Redefine Management of Estrogen Receptor–Positive Breast Cancer","year":2025,"lang":"en","type":"review","venue":"Annual Review of Medicine","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Estrogen receptor; Estrogen; Breast cancer; Medicine; Selective estrogen receptor modulator; Discontinuation; Endocrine system; Estrogen-related receptor alpha; Estrogen receptor beta; Cancer; Pharmacology; Cancer research; Internal medicine; Bioinformatics; Hormone; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006341678,0.0007463032,0.002964294,0.0001661254,0.0000505476,0.000003406122,0.0006047927,0.0005495829,0.0001908452],"category_scores_gemma":[0.0001455559,0.0005285893,0.0008302881,0.0008899614,0.0002816553,0.000007295351,0.0002496735,0.0004568061,0.00001672788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001025446,"about_ca_system_score_gemma":0.0007593152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000180138,"about_ca_topic_score_gemma":0.000001619547,"domain_scores_codex":[0.9964132,0.0004275512,0.001466536,0.0007782584,0.0004703961,0.0004440422],"domain_scores_gemma":[0.9974837,0.00007406106,0.001112716,0.0006647528,0.0004120607,0.0002527204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007743175,0.00006547513,0.000008826501,0.1061716,0.002480872,0.000007895026,0.00002242797,2.434275e-7,0.00009148874,0.0002216296,0.1211714,0.7696807],"study_design_scores_gemma":[0.0006773239,0.0006648246,0.000003506192,0.2629517,0.004652523,0.00005482408,0.0000512517,7.495898e-8,0.0004504658,0.000005157828,0.7301459,0.0003423895],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000009262765,0.9943038,0.00004826906,0.0006486389,0.0004768667,0.001981489,0.0008586842,0.00001542488,0.001657606],"genre_scores_gemma":[0.000005875642,0.9938992,0.0009939887,0.0002548108,0.00045763,0.0001635019,0.002035668,0.00006767139,0.002121703],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7693383,"threshold_uncertainty_score":0.9997166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009586657653928089,"score_gpt":0.3271402371955652,"score_spread":0.3175535795416372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}