{"id":"W4406865814","doi":"10.1016/j.ijbiomac.2025.140351","title":"Interactions between PEI and biological polyanions and the ability of glycosaminoglycans in destabilizing PEI/peGFP-C3 polyplexes for genetic material release","year":2025,"lang":"en","type":"article","venue":"International Journal of Biological Macromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Circulatory and Respiratory Health; Centre National de la Recherche Scientifique; Consejo Nacional de Ciencia y Tecnología; Agence Nationale de la Recherche","keywords":"Chemistry; Polyelectrolyte; Dissociation (chemistry); DNA; Static electricity; Glycosaminoglycan; Biophysics; Heparin; Gene delivery; Chondroitin sulfate; Polymer; Biochemistry; Transfection; Organic chemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003108273,0.0002479611,0.0001076573,0.0001536875,0.0002408182,0.000301461,0.0001863199,0.0002981403,0.0009246832],"category_scores_gemma":[0.0004134562,0.0001678642,0.0001683957,0.0001303745,0.0003194934,0.0003584131,0.0002046386,0.0004371106,0.0001360524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004062796,"about_ca_system_score_gemma":0.0003465725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001244236,"about_ca_topic_score_gemma":0.001679869,"domain_scores_codex":[0.9997719,0.00004532564,0.0000211959,0.00004505619,0.00006829492,0.00004823831],"domain_scores_gemma":[0.999767,0.00009175793,0.00005894114,0.00001191016,0.00003186336,0.00003851454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007899956,0.00001107627,0.00007948617,0.00002644106,0.000004463745,0.00002722682,0.00002019917,0.00009736972,0.9990178,0.0001545093,0.00001416744,0.00046833],"study_design_scores_gemma":[0.000002793836,0.00003888967,0.000419145,0.000001230231,0.000003826705,0.00002432398,0.000005631187,0.0003931226,0.998853,0.00001428894,0.0002414543,0.000002416886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955764,0.0005062611,0.002454434,0.00005357062,0.00001487282,0.00002659277,0.00005831252,0.00003054243,0.001279158],"genre_scores_gemma":[0.9969926,0.0001729349,0.001541188,0.000027041,0.000003078544,0.00001936165,0.00007252326,0.000009080763,0.001162064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244236,"threshold_uncertainty_score":0.003093362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01982765107614339,"score_gpt":0.3017089087830052,"score_spread":0.2818812577068618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}