{"id":"W4406866107","doi":"10.1016/j.ijbiomac.2025.140387","title":"The neuroprotective effect of human umbilical cord MSCs-derived secretome against α-synuclein aggregates on the blood-brain barrier","year":2025,"lang":"en","type":"article","venue":"International Journal of Biological Macromolecules","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute for Genetic Engineering and Biotechnology; Iran National Science Foundation; Lundbeckfonden","keywords":"Mesenchymal stem cell; Blood–brain barrier; Neuroprotection; Umbilical cord; Cytotoxicity; Inflammation; Paracrine signalling; Neurotoxicity; Cell biology; In vitro; Medicine; Chemistry; Immunology; Biology; Pharmacology; Central nervous system; Neuroscience; Toxicity; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008969739,0.0002259252,0.0002429142,0.000143639,0.0001306651,0.0002988141,0.00009312062,0.0002259836,0.00119477],"category_scores_gemma":[0.0001027523,0.00004505989,0.0002291411,0.0001100798,0.0001343658,0.0002883806,0.0001441367,0.000516118,0.0001701663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001369477,"about_ca_system_score_gemma":0.0003055382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006456394,"about_ca_topic_score_gemma":0.0008317988,"domain_scores_codex":[0.9999418,0.000005914835,0.000005498174,0.000009435415,0.00001725677,0.00002011162],"domain_scores_gemma":[0.999964,0.000005317515,0.000006570985,0.000003583116,0.000007066297,0.00001349727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001074651,0.0001752207,0.0004208163,0.0001137012,0.00002466975,0.000152905,0.00005751298,0.0001087781,0.9905269,0.0002138269,0.0002328978,0.006898123],"study_design_scores_gemma":[0.0001024565,0.0007495421,0.006214631,0.00001750798,0.00009539902,0.0002047512,0.00009520018,0.0007650873,0.9884952,0.0001581623,0.003095386,0.000006577274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996123,0.001647394,0.0007046932,0.0001322083,0.00008239158,0.00001454783,0.0002350437,0.00002216698,0.001038466],"genre_scores_gemma":[0.9970354,0.001052002,0.0004391233,0.00007076001,0.0000242825,0.00001554428,0.0003023426,0.000005621444,0.001055127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00119477,"threshold_uncertainty_score":0.003996909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01423500652915229,"score_gpt":0.2995373088588111,"score_spread":0.2853023023296589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}