{"id":"W4406869451","doi":"10.1128/spectrum.00885-24","title":"Ectopic overexpression of <i>Plasmodium falciparum</i> DNA-/RNA-binding Alba proteins misregulates virulence gene homeostasis during asexual blood development","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Malaria Research and Control","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Agence Nationale de la Recherche; Department of Biotechnology, Ministry of Science and Technology, India; Alliance Française contre les Maladies Parasitaires","keywords":"Biology; Gene; Chromatin; Gene expression; Regulation of gene expression; Genetics; RNA; Subtelomere; Cell biology; Molecular biology; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002644329,0.0002804269,0.0005791219,0.0003562885,0.0002122008,0.0000190872,0.0002846783,0.0002473571,0.0003365541],"category_scores_gemma":[0.0001017634,0.0002383189,0.0001157693,0.000297403,0.0001793693,0.00005569651,0.0002629065,0.0003474492,0.00003983661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001372716,"about_ca_system_score_gemma":0.0004110482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000596397,"about_ca_topic_score_gemma":0.00004758064,"domain_scores_codex":[0.9979408,0.0001179469,0.0005153237,0.0005463288,0.0001301255,0.0007494655],"domain_scores_gemma":[0.999131,0.00007644173,0.000151293,0.000437582,0.00006830057,0.0001353916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006977714,0.0003122751,0.005471103,0.0002988586,0.0003957011,0.00005486936,0.0001006353,0.00000311326,0.9916139,0.0002262702,0.0002011277,0.000624414],"study_design_scores_gemma":[0.003982206,0.0002787768,0.02050763,0.0004183543,0.00008377331,0.0001083852,0.00004890793,0.000008397261,0.9730129,0.00007170692,0.001287534,0.0001914842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949738,0.0009086969,0.0001518418,0.002206872,0.0001355118,0.0009073284,0.00006086813,0.00006708776,0.0005880223],"genre_scores_gemma":[0.9948423,0.00006362813,0.001615273,0.0001471003,0.00007264091,0.0000840413,0.0001072752,0.00001972138,0.003048002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01860102,"threshold_uncertainty_score":0.9718361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008666869402289586,"score_gpt":0.2434655943278138,"score_spread":0.2347987249255243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}