{"id":"W4406870189","doi":"10.1200/jco.2025.43.4_suppl.tps507","title":"CLARITY-Gastric 01: A randomized phase 3 study of AZD0901, a Claudin18.2 (CLDN18.2)-targeted antibody-drug conjugate, in second- or later-line (2L+) advanced gastric or gastroesophageal junction cancer (GC/GEJC).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Cancer; Gastroesophageal Junction; Conjugate; Drug; Gemcitabine; Internal medicine; Pharmacology; Adenocarcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.006436759,0.0004680561,0.005720153,0.001452004,0.00007937186,0.00002577288,0.0004062202,0.0004013847,0.001622767],"category_scores_gemma":[0.005023629,0.0002996156,0.0008943769,0.001977196,0.0003175163,0.00031648,0.0001785332,0.002060097,0.00000595133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005337598,"about_ca_system_score_gemma":0.00299976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002339979,"about_ca_topic_score_gemma":0.002031095,"domain_scores_codex":[0.990079,0.001622605,0.006358311,0.0005754256,0.0007070079,0.0006576615],"domain_scores_gemma":[0.9907466,0.003823449,0.00387505,0.0004240143,0.0007347217,0.000396186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7211481,0.01409266,0.1695149,0.0003460009,0.00250231,0.002753983,0.0003129663,0.0004314589,0.0005208066,0.00001565053,0.006065469,0.08229566],"study_design_scores_gemma":[0.7566299,0.02931917,0.1997683,0.0005480236,0.003141837,0.0001802088,0.001312312,0.001175725,0.00008780834,0.00009585839,0.00750257,0.0002382512],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885024,0.0009564154,0.00118848,0.002920735,0.003551631,0.002387782,0.00001909333,0.00003570164,0.0004377463],"genre_scores_gemma":[0.9875903,0.002247319,0.002446837,0.00201713,0.0007945326,0.0000787231,0.00001988979,0.00003663678,0.004768594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08205741,"threshold_uncertainty_score":0.9999456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0657563796571697,"score_gpt":0.4718150881781101,"score_spread":0.4060587085209404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}