{"id":"W4406870189","doi":"10.1200/jco.2025.43.4_suppl.tps507","title":"CLARITY-Gastric 01: A randomized phase 3 study of AZD0901, a Claudin18.2 (CLDN18.2)-targeted antibody-drug conjugate, in second- or later-line (2L+) advanced gastric or gastroesophageal junction cancer (GC/GEJC).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Cancer; Gastroesophageal Junction; Conjugate; Drug; Gemcitabine; Internal medicine; Pharmacology; Adenocarcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002253218,0.001734906,0.00204769,0.0003474132,0.0004450415,0.001497357,0.001148962,0.002305615,0.008997479],"category_scores_gemma":[0.001574548,0.0007459479,0.001737719,0.0003988972,0.001135851,0.001394998,0.0005177808,0.004358809,0.001713121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00111166,"about_ca_system_score_gemma":0.001570063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001312071,"about_ca_topic_score_gemma":0.004017909,"domain_scores_codex":[0.9995116,0.0002391893,0.00001846,0.00009902871,0.00004489654,0.00008674966],"domain_scores_gemma":[0.9992787,0.0001239908,0.0001527535,0.00006263555,0.00005929423,0.0003226812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9231017,0.02168037,0.00171399,0.001228814,0.001790605,0.0001210657,0.000139704,0.0006782497,0.009665118,0.000414251,0.008625457,0.03084077],"study_design_scores_gemma":[0.912474,0.08150657,0.002111781,0.00004038257,0.0004906934,0.00007897954,0.00003482995,0.0004072546,0.0004212321,0.000240489,0.002174412,0.00001942372],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579569,0.01020757,0.001471419,0.002829083,0.001483904,0.01215288,0.006104863,0.0006023453,0.007191054],"genre_scores_gemma":[0.9530398,0.006205564,0.004236673,0.007014158,0.0007304209,0.01234251,0.008016525,0.0001598934,0.008254426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008997479,"threshold_uncertainty_score":0.03009951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0657563796571697,"score_gpt":0.4718150881781101,"score_spread":0.4060587085209404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}