{"id":"W4406872856","doi":"10.26434/chemrxiv-2025-fvct3","title":"Harnessing a Ketone-Accepting Pictet-Spenglerase for the Asymmetric Construction of 1,1-Disubstituted Tetrahydro-ß-Carboline Alkaloids","year":2025,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Natural Sciences and Engineering Research Council of Canada; Japan Science and Technology Agency; New Energy and Industrial Technology Development Organization; National Institutes of Health","keywords":"Ketone; Pictet–Spengler reaction; Chemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002408192,0.0004395537,0.0001924586,0.0001737733,0.000121726,0.0003337653,0.0003148705,0.0003866196,0.0006662235],"category_scores_gemma":[0.0001904424,0.000165027,0.0002220758,0.0001871268,0.0002563098,0.000377641,0.0003502237,0.0006172154,0.0005698802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003033353,"about_ca_system_score_gemma":0.0002441797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003317103,"about_ca_topic_score_gemma":0.0005691045,"domain_scores_codex":[0.9998341,0.0000340277,0.00001609543,0.00003793472,0.00003987752,0.0000379686],"domain_scores_gemma":[0.9999232,0.000009632113,0.00002745933,0.00001337656,0.000006536828,0.00001978491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000353195,0.00003866059,0.0001266229,0.00006550142,0.000006289123,0.0001292068,0.00003676074,0.0002650474,0.9949464,0.0005575134,0.00007935263,0.00371331],"study_design_scores_gemma":[0.000009277128,0.0001393882,0.0003530032,0.000004059124,0.000005183783,0.0002043395,0.00001247614,0.0009964783,0.9961279,0.000053568,0.002085665,0.000008627547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9499003,0.001828542,0.04015582,0.0002455844,0.00005423725,0.0001536504,0.0004092151,0.0003656425,0.00688693],"genre_scores_gemma":[0.9755318,0.0009426191,0.02053908,0.00005980995,0.000008374853,0.0000457465,0.0003757226,0.00003528905,0.002461463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006662235,"threshold_uncertainty_score":0.002228737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767277186878367,"score_gpt":0.2769404261282063,"score_spread":0.2592676542594226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}