{"id":"W4406873201","doi":"10.1016/j.jtho.2025.01.016","title":"Gene Copy Deletion of STK11, KEAP1, and SMARCA4: Clinicopathologic Features and Association With the Outcomes of Immunotherapy With or Without Chemotherapy in Nonsquamous NSCLC","year":2025,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institut Du Cancer de Montréal; Terry Fox Research Institute; Ministry of Scientific Research, Egypt; Fondation du CHUM; Society for Immunotherapy of Cancer; American Society of Clinical Oncology; Melanoma Research Alliance","keywords":"Medicine; STK11; Lung cancer; Immunotherapy; Chemotherapy; Oncology; Gene; SMARCA4; Internal medicine; Cancer research; Cancer; Gene expression; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002843569,0.0002328044,0.0002261209,0.0005437575,0.0002738767,0.000503873,0.0003323789,0.0004346498,0.001652353],"category_scores_gemma":[0.001123425,0.0001873671,0.0002550278,0.0006189496,0.0003626966,0.0003420483,0.0002370331,0.0002928555,0.0002362511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002445047,"about_ca_system_score_gemma":0.0002454645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006761251,"about_ca_topic_score_gemma":0.0008184127,"domain_scores_codex":[0.9998197,0.00003356759,0.00002556231,0.00005121072,0.00002837859,0.00004171216],"domain_scores_gemma":[0.999215,0.0001933513,0.0003137793,0.00005508009,0.00004781331,0.0001749769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008037665,0.00002609999,0.9911435,0.000009605102,0.00003697011,0.001145051,0.00004111998,0.0001371924,0.004870273,0.00004171538,0.0000738786,0.001670857],"study_design_scores_gemma":[0.00001524294,0.0001207896,0.9938502,0.000003369177,0.00005120998,0.004137067,0.0001813651,0.0005950484,0.0006707832,0.00009460295,0.0002740583,0.000006155622],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994423,0.0001510136,0.0000489875,0.00001772943,0.000003033919,0.000001879439,0.00009183316,0.000002326622,0.0002409408],"genre_scores_gemma":[0.9996988,0.00003581993,0.00002540239,0.000004635971,0.000005159232,0.000002035468,0.0001178579,9.591853e-7,0.0001094276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001652353,"threshold_uncertainty_score":0.005527675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009004910959578238,"score_gpt":0.3621549340082238,"score_spread":0.3531500230486456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}