{"id":"W4406873201","doi":"10.1016/j.jtho.2025.01.016","title":"Gene Copy Deletion of STK11, KEAP1, and SMARCA4: Clinicopathologic Features and Association With the Outcomes of Immunotherapy With or Without Chemotherapy in Nonsquamous NSCLC","year":2025,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institut Du Cancer de Montréal; Terry Fox Research Institute; Ministry of Scientific Research, Egypt; Fondation du CHUM; Society for Immunotherapy of Cancer; American Society of Clinical Oncology; Melanoma Research Alliance","keywords":"Medicine; STK11; Lung cancer; Immunotherapy; Chemotherapy; Oncology; Gene; SMARCA4; Internal medicine; Cancer research; Cancer; Gene expression; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008700134,0.0001072727,0.0004175747,0.00007274357,0.00003168422,0.000007766447,0.0001032049,0.0001807528,0.000003332419],"category_scores_gemma":[0.00006306783,0.00005555217,0.00004446511,0.0001000547,0.0001268408,0.000005476601,0.00002053667,0.0001683371,2.656793e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005056744,"about_ca_system_score_gemma":0.0002655283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002269769,"about_ca_topic_score_gemma":0.0002068963,"domain_scores_codex":[0.999105,0.000194507,0.0003511765,0.0001224569,0.0001214608,0.0001054007],"domain_scores_gemma":[0.9988568,0.0001191019,0.0006801345,0.0001247335,0.000200188,0.00001908777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01781562,0.0003515068,0.5578277,0.00009113437,0.0005352438,0.0000122754,0.000674875,0.0002879875,0.285323,0.000008842433,0.0004770296,0.1365948],"study_design_scores_gemma":[0.01094787,0.01388268,0.678647,0.0003988301,0.0003919553,0.0006775915,0.001662949,0.000236787,0.2897702,0.0002287403,0.002811096,0.0003442819],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938919,0.003005327,0.001164359,0.001634897,0.00005784943,0.0001518513,0.000003896646,0.000001674644,0.00008826606],"genre_scores_gemma":[0.9923774,0.002613819,0.004242408,0.0004606911,0.00003418059,0.000004860157,0.000001978538,0.000008701708,0.0002559847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1362505,"threshold_uncertainty_score":0.2265352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009004910959578238,"score_gpt":0.3621549340082238,"score_spread":0.3531500230486456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}