{"id":"W4406877719","doi":"10.1161/circulationaha.124.072285","title":"SLICE-CEA CardioLink-8: A Randomized Trial of Evolocumab on Carotid Artery Atherosclerotic Plaque Characteristics in Asymptomatic High-Risk Carotid Stenosis","year":2025,"lang":"en","type":"letter","venue":"Circulation","topic":"Cerebrovascular and Carotid Artery Diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Artificial Intelligence in Medicine (Canada); North York General Hospital; Sunnybrook Health Science Centre; Public Health Ontario; University of Toronto; St. Michael's Hospital","funders":"","keywords":"Medicine; Stenosis; Asymptomatic; Cardiology; Evolocumab; Internal medicine; Carotid arteries; Randomized controlled trial; Radiology; Cholesterol; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001381167,0.0007104591,0.002157182,0.0002569768,0.0005087616,0.001054495,0.000759266,0.005285767,0.005647328],"category_scores_gemma":[0.004961831,0.0003151177,0.0009557596,0.0003219119,0.0005022144,0.0006074025,0.0002133598,0.005058249,0.001542024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001169881,"about_ca_system_score_gemma":0.001099065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002232133,"about_ca_topic_score_gemma":0.007808966,"domain_scores_codex":[0.9992974,0.0003922288,0.00004799804,0.00008415247,0.00008061659,0.00009751492],"domain_scores_gemma":[0.9981881,0.001063397,0.0001547537,0.00006899464,0.0001387227,0.0003859142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4317463,0.002817499,0.01971734,0.001437206,0.003410023,0.004210801,0.0001873784,0.00093788,0.004883366,0.003111549,0.3722486,0.1552921],"study_design_scores_gemma":[0.8099418,0.01843392,0.05039898,0.0009315288,0.004612649,0.002326654,0.0002908239,0.005183745,0.002354659,0.00835086,0.09700107,0.0001733664],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.4147394,0.03676606,0.001131486,0.4365814,0.0480224,0.00107966,0.005725538,0.0005503964,0.05540371],"genre_scores_gemma":[0.6668456,0.006289479,0.001831882,0.2681954,0.02938786,0.000916419,0.002081139,0.0001026012,0.02434954],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005647328,"threshold_uncertainty_score":0.01889223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01063686909136377,"score_gpt":0.2301931844192862,"score_spread":0.2195563153279224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}