{"id":"W4406887532","doi":"10.1111/jnc.16310","title":"Prion Protein Endoproteolysis: Cleavage Sites, Mechanisms and Connections to Prion Disease","year":2025,"lang":"en","type":"review","venue":"Journal of Neurochemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute; Canadian Institutes of Health Research; Alzheimer Society; University of Alberta; Campus Alberta Neuroscience","keywords":"Proteases; Cleavage (geology); Biology; Gene isoform; In vitro; Cell biology; Prion protein; Neurodegeneration; Disease; Biochemistry; Enzyme; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005241762,0.0006884398,0.0007756752,0.001560298,0.0001888108,0.001169778,0.0004854662,0.0008967706,0.0004753742],"category_scores_gemma":[0.0004415081,0.0002296575,0.0004081489,0.00141725,0.0007484497,0.001059249,0.0005038765,0.001107211,0.0003846285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000400799,"about_ca_system_score_gemma":0.0003044722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003023556,"about_ca_topic_score_gemma":0.0002265093,"domain_scores_codex":[0.9998178,0.00003510443,0.00002630803,0.00004620097,0.00004698849,0.00002763544],"domain_scores_gemma":[0.9997327,0.00009912924,0.00008574757,0.000009286704,0.00005016549,0.00002299874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009447281,0.000311423,0.007593961,0.04047047,0.0005424351,0.005988544,0.001077701,0.002953992,0.1878546,0.04151649,0.01206063,0.6986851],"study_design_scores_gemma":[0.0001254082,0.002256408,0.0665822,0.00857251,0.001052568,0.04276936,0.001088882,0.003475476,0.08629439,0.09581535,0.6916801,0.0002873311],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00492548,0.9934967,0.0006313868,0.0001885951,0.0000929492,0.00000488201,0.0000243309,0.000006530361,0.0006291583],"genre_scores_gemma":[0.03586953,0.9617234,0.0009208207,0.0002689447,0.0004351554,0.00001161328,0.00007815816,0.000002918885,0.0006895757],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001560298,"threshold_uncertainty_score":0.002907991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599726901549522,"score_gpt":0.2984379296860654,"score_spread":0.2824406606705702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}