{"id":"W4406906787","doi":"10.1210/clinem/dgaf039","title":"Insulitis and Exocrinitis in Autoantibody-positive Nondiabetic Individuals: Role of HLA Genotypes","year":2025,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"Juvenile Diabetes Research Foundation Australia; Fondation Francophone pour la Recherche sur le Diabète; Agence Nationale de la Recherche; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Autoantibody; Insulitis; Immunology; Autoimmunity; Type 1 diabetes; Human leukocyte antigen; Medicine; Islet; Internal medicine; Haplotype; Diabetes mellitus; Endocrinology; Allele; Biology; Antibody; Antigen; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009501882,0.0001437403,0.0006398959,0.000139574,0.00004559512,0.00000996377,0.0003535376,0.0001718002,0.00001253854],"category_scores_gemma":[0.0009871628,0.000105122,0.0001839298,0.0001654787,0.000418909,0.0000090278,0.0002014333,0.0004223076,0.000001579416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003994454,"about_ca_system_score_gemma":0.0001629305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005072041,"about_ca_topic_score_gemma":0.00002553621,"domain_scores_codex":[0.9977593,0.0006233742,0.001018031,0.0001646871,0.0001257264,0.000308814],"domain_scores_gemma":[0.9986318,0.0004034389,0.0005356207,0.0002012275,0.0001673407,0.00006060554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009459528,0.001351529,0.5623431,0.00006622962,0.003002168,0.00004425353,0.0008006127,0.000122019,0.08875442,0.01327681,0.001714726,0.3275782],"study_design_scores_gemma":[0.002981236,0.0004365708,0.9264921,0.0000763327,0.0003663595,0.00003401487,0.0006129808,0.00001345943,0.02753584,0.007482789,0.03381928,0.0001490648],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677314,0.02918453,0.00002458909,0.001198562,0.0002961844,0.0001044848,0.00002342653,0.000002671476,0.001434152],"genre_scores_gemma":[0.9838598,0.01488034,0.0002135793,0.0007708495,0.0001392355,0.00000230511,0.000005977112,0.00000992798,0.0001179425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.364149,"threshold_uncertainty_score":0.428675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008428212361442979,"score_gpt":0.3127135177268155,"score_spread":0.3042853053653725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}