{"id":"W4406906787","doi":"10.1210/clinem/dgaf039","title":"Insulitis and Exocrinitis in Autoantibody-positive Nondiabetic Individuals: Role of HLA Genotypes","year":2025,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"Juvenile Diabetes Research Foundation Australia; Fondation Francophone pour la Recherche sur le Diabète; Agence Nationale de la Recherche; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Autoantibody; Insulitis; Immunology; Autoimmunity; Type 1 diabetes; Human leukocyte antigen; Medicine; Islet; Internal medicine; Haplotype; Diabetes mellitus; Endocrinology; Allele; Biology; Antibody; Antigen; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000620718,0.0002070369,0.0001911346,0.0006939026,0.0003809685,0.0003416491,0.0001564025,0.0003401601,0.001613978],"category_scores_gemma":[0.001959392,0.0001449653,0.0001729445,0.0004519172,0.0004121531,0.0002577129,0.0003570954,0.0002722054,0.0001302614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000114744,"about_ca_system_score_gemma":0.000146525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005204607,"about_ca_topic_score_gemma":0.0007181608,"domain_scores_codex":[0.9997669,0.00006704848,0.00002683967,0.00005140893,0.00003894657,0.00004891026],"domain_scores_gemma":[0.9987495,0.0004151181,0.0005034262,0.00006712656,0.00004548764,0.0002193621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001753006,0.00001939995,0.9972903,0.000007389806,0.000009324279,0.0004981491,0.00005961296,0.00001176856,0.0005702667,0.00001026679,0.00001649586,0.001331832],"study_design_scores_gemma":[0.000009195744,0.0001294473,0.9949313,0.00000655387,0.00001953903,0.004325901,0.0001849195,0.00008382579,0.000168184,0.00003507584,0.0001036313,0.000002470916],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996841,0.0001414409,0.00002303759,0.000008191198,0.000001644709,0.000001743503,0.00001002442,6.988555e-7,0.0001291266],"genre_scores_gemma":[0.9998484,0.00005335642,0.00003496697,0.000007046073,0.000006400752,0.000001402532,0.00001908757,4.397551e-7,0.00002878799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001613978,"threshold_uncertainty_score":0.005399287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008428212361442979,"score_gpt":0.3127135177268155,"score_spread":0.3042853053653725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}