{"id":"W4406920607","doi":"10.1371/journal.pcbi.1012772","title":"Specificity and tunability of efflux pumps: A new role for the proton gradient?","year":2025,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Los Alamos National Laboratory; National Nuclear Security Administration; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; U.S. Department of Energy","keywords":"Efflux; Electrochemical gradient; Periplasmic space; Membrane potential; Transmembrane protein; Biophysics; Diaphragm pump; Proton; Proton pump; Membrane; Chemistry; Biological system; Biology; Biochemistry; Nanotechnology; Physics; Materials science; ATPase; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006758876,0.0003771848,0.0007567814,0.0002058313,0.0003161577,0.001145506,0.000785974,0.001040073,0.001586522],"category_scores_gemma":[0.002313287,0.0003505744,0.0005976557,0.0001775827,0.001519657,0.005030599,0.001055349,0.001324085,0.0002415479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000543407,"about_ca_system_score_gemma":0.0004138847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006194288,"about_ca_topic_score_gemma":0.0003863252,"domain_scores_codex":[0.9997522,0.00006552308,0.00001304402,0.00007088411,0.00004947277,0.00004895168],"domain_scores_gemma":[0.9992425,0.0003920218,0.0001043564,0.0001383253,0.00005533428,0.00006738488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004074311,0.0001276372,0.008479452,0.0006906923,0.0001750935,0.0008007622,0.0004904407,0.14394,0.2429875,0.5266092,0.001635942,0.07365587],"study_design_scores_gemma":[0.00006496063,0.0004897852,0.004830255,0.00008834291,0.00008732384,0.000838502,0.0003421352,0.5001964,0.0460603,0.4327706,0.01401494,0.0002164124],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6418681,0.01324624,0.3178623,0.01126902,0.0003285734,0.00003655618,0.0001982927,0.0005549739,0.0146361],"genre_scores_gemma":[0.9869741,0.002950388,0.008435119,0.0003364987,0.00007629369,0.00001844702,0.0000386366,0.00004339946,0.001127203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001586522,"threshold_uncertainty_score":0.005307436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01244626314514376,"score_gpt":0.2727662883801583,"score_spread":0.2603200252350145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}