{"id":"W4406925020","doi":"10.1016/j.ebiom.2025.105576","title":"Genetic insights into psychotic major depressive disorder: bridging the mood-psychotic disorder spectrum","year":2025,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Uppsala Multidisciplinary Center for Advanced Computational Science; European Research Council; South East Regional Health Authority; Norges Forskningsråd; Novo Nordisk Fonden; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; National Institutes of Health; National Institute of Mental Health; Vetenskapsrådet; Novo Nordisk; Stiftelsen för Strategisk Forskning; Hjärnfonden; European Commission; Stiftelsen för Miljöstrategisk Forskning","keywords":"Bridging (networking); Schizophrenia spectrum; Spectrum disorder; Major depressive disorder; Psychiatry; Mood; Medicine; Psychology; Clinical psychology; Psychosis; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002195958,0.0002671901,0.0003119385,0.0001379783,0.0003630454,0.00002067654,0.000433671,0.00020281,0.00005611306],"category_scores_gemma":[0.0002310429,0.0001855684,0.000121821,0.0004281229,0.0002916025,0.000003116604,0.0001453354,0.0001980817,0.00003468965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002826873,"about_ca_system_score_gemma":0.00008487057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002943859,"about_ca_topic_score_gemma":0.0008339949,"domain_scores_codex":[0.9982136,0.0001730807,0.0004558533,0.0005620603,0.0001559119,0.0004394159],"domain_scores_gemma":[0.9988571,0.00007837269,0.000160502,0.0007431936,0.00006755949,0.00009328854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002488717,0.0006717069,0.7813362,0.0001837748,0.001327865,0.00001683564,0.001174867,0.001664845,0.06123223,0.001309431,0.09485643,0.05597688],"study_design_scores_gemma":[0.00311234,0.0004013928,0.8612848,0.00008222723,0.0002243516,0.00002000098,0.0004081829,0.002069455,0.0008936173,0.009637912,0.1214658,0.0003999337],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9030905,0.01606187,0.05878819,0.01839604,0.00106019,0.0004787917,0.000004713656,0.00002951298,0.002090136],"genre_scores_gemma":[0.9926408,0.001292969,0.0006016826,0.002244038,0.0005800514,0.00007939266,0.00009223487,0.00002706577,0.002441759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08955025,"threshold_uncertainty_score":0.756726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004326561885429019,"score_gpt":0.2616912958925854,"score_spread":0.2573647340071564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}