{"id":"W4406927552","doi":"10.1128/msphere.01078-24","title":"Structural analysis of extracellular ATP-independent chaperones of streptococcal species and protein substrate interactions","year":2025,"lang":"en","type":"article","venue":"mSphere","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"Argonne National Laboratory; Office of Science; National Institute of General Medical Sciences; Michigan Technology Tri-Corridor; Directorate for Biological Sciences; U.S. Department of Health and Human Services; National Institutes of Health; National Institute of Allergy and Infectious Diseases; University of Pittsburgh; Northwestern University; U.S. Department of Energy","keywords":"Foldase; Pneumolysin; Virulence; Biology; Chaperone (clinical); Peptidylprolyl isomerase; Cyclophilin; Secretion; Microbiology; Streptococcus pneumoniae; Protein folding; Extracellular; Streptococcus pyogenes; Isomerase; Cell biology; Biochemistry; Bacteria; GroEL; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005416402,0.00009773778,0.0001764978,0.00004655008,0.00003097081,0.00001019827,0.0001092325,0.00006238339,0.0002290598],"category_scores_gemma":[0.00003775423,0.00009161053,0.0001161976,0.000187652,0.0001089262,0.000003342586,0.00007164896,0.00005184259,3.810291e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007121375,"about_ca_system_score_gemma":0.00004350557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003401769,"about_ca_topic_score_gemma":0.0001592286,"domain_scores_codex":[0.9993506,0.00003329221,0.0002241415,0.0002103793,0.00008527518,0.00009633314],"domain_scores_gemma":[0.9995244,0.00001042813,0.0001026224,0.0002491502,0.00007897929,0.00003443646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007132194,0.00003650314,0.04864118,0.00005324842,0.0005463472,0.00000166754,0.00006471402,0.0004775782,0.9491011,0.0004507507,0.00003268059,0.0005229226],"study_design_scores_gemma":[0.0002538792,0.00005865566,0.0812251,0.00003348783,0.0003133191,6.407124e-7,0.0004252637,0.0005668972,0.9163178,0.00006963257,0.0006419809,0.00009337885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976775,0.001094479,0.0003780543,0.0000336469,0.0000472669,0.0001648812,0.00006649446,0.000005456725,0.0005322269],"genre_scores_gemma":[0.9976787,0.000008014127,0.0002424701,0.000006735085,0.00002040681,0.00001508941,0.00005828034,0.000005709932,0.001964591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03278332,"threshold_uncertainty_score":0.3735769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252443973226718,"score_gpt":0.2585577048721447,"score_spread":0.2460332651398775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}