{"id":"W4406927863","doi":"10.14309/ajg.0000000000003330","title":"Body Mass Index Did Not Affect Efficacy and Safety of Etrasimod: A Post Hoc Analysis of the ELEVATE Ulcerative Colitis Clinical Program","year":2025,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Pfizer","keywords":"Medicine; Internal medicine; Placebo; Gastroenterology; Body mass index; Calprotectin; Post-hoc analysis; Clinical endpoint; Clinical trial; Ulcerative colitis; Subgroup analysis; Inflammatory bowel disease; Confidence interval; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006136562,0.001141121,0.003724346,0.0003564962,0.0003362356,0.001082714,0.0007027827,0.0009236152,0.006419596],"category_scores_gemma":[0.007115979,0.0004636649,0.003940334,0.0003574353,0.0008416233,0.0008836898,0.0007117983,0.002446497,0.0004866254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005988058,"about_ca_system_score_gemma":0.001361012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006732011,"about_ca_topic_score_gemma":0.001057832,"domain_scores_codex":[0.9956495,0.002425536,0.0002425688,0.0006156631,0.0004136677,0.0006530415],"domain_scores_gemma":[0.9916789,0.00495595,0.001054255,0.0009274512,0.0004723066,0.0009111588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9544707,0.005219337,0.01568379,0.0001918558,0.004881662,0.0001289137,0.0001068547,0.0007340442,0.007380851,0.0000730762,0.001080432,0.0100485],"study_design_scores_gemma":[0.0690783,0.5544789,0.3441737,0.00006337857,0.01266432,0.0001916621,0.0002341182,0.006520336,0.008702894,0.0003196172,0.003465894,0.0001068232],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973708,0.0002959926,0.0003371802,0.0001078503,0.00009466142,0.0003249987,0.0006284504,0.00002356295,0.0008165112],"genre_scores_gemma":[0.9962069,0.00009993925,0.0004967232,0.0001657022,0.0001101363,0.0006148204,0.0007306031,0.0000245187,0.001550788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006419596,"threshold_uncertainty_score":0.03245366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005643464446565352,"score_gpt":0.296103211963664,"score_spread":0.2904597475170987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}