{"id":"W4406932818","doi":"10.1038/s41586-025-08696-7","title":"Editorial Expression of Concern: 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark","year":2025,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Ubiquitin; DNA damage; DNA; Molecular biology; Cell biology; Chemistry; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002678363,0.002271286,0.002135366,0.001722793,0.001894673,0.00428866,0.002249735,0.01099554,0.01476243],"category_scores_gemma":[0.01431639,0.0008637691,0.00172026,0.0005803967,0.00164131,0.002576791,0.001037508,0.01624121,0.01152491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002022299,"about_ca_system_score_gemma":0.001547893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001039487,"about_ca_topic_score_gemma":0.002295364,"domain_scores_codex":[0.9975738,0.0003142654,0.0002375709,0.0004270616,0.001247152,0.0002001525],"domain_scores_gemma":[0.9882708,0.003047576,0.0009890613,0.0003550949,0.004925897,0.00241149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003771499,0.000008797841,0.00003467837,0.00008883599,0.00001098159,0.0001436344,0.000007638312,0.00001633577,0.0001055211,0.0001617971,0.9957685,0.003615643],"study_design_scores_gemma":[0.00004590144,0.00005572351,0.0003612465,0.0001825287,0.00003814268,0.0006161244,0.00003873477,0.000190756,0.0002888312,0.0006371705,0.9975222,0.00002250983],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.00007968265,0.00269834,0.0001728285,0.0541706,0.9413478,0.00001537869,0.00005574647,0.00007547338,0.001384188],"genre_scores_gemma":[0.001006267,0.001934765,0.0001040367,0.03945319,0.9459202,0.0000187293,0.00003773016,0.00003188879,0.01149327],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.9890044,"threshold_uncertainty_score":0.04938525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00860370617287917,"score_gpt":0.3139422950973353,"score_spread":0.3053385889244561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}