{"id":"W4406934683","doi":"10.1016/j.atherosclerosis.2025.119114","title":"Familial chylomicronemia syndrome and treatments to target hepatic APOC3 mRNA","year":2025,"lang":"en","type":"review","venue":"Atherosclerosis","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Chicoutimi","funders":"Ionis Pharmaceuticals","keywords":"Messenger RNA; Medicine; Genetics; Internal medicine; Endocrinology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000470192,0.001059589,0.001785459,0.001789473,0.000176848,0.0007461211,0.00069225,0.001083925,0.0043389],"category_scores_gemma":[0.0007093313,0.0002798783,0.0006727775,0.001481936,0.0003037618,0.0007356553,0.0004418493,0.001776789,0.001532168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004544744,"about_ca_system_score_gemma":0.0007858359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009362837,"about_ca_topic_score_gemma":0.002134632,"domain_scores_codex":[0.9998767,0.00002141914,0.00002383019,0.00002281304,0.00004067981,0.00001456791],"domain_scores_gemma":[0.9997595,0.0001226584,0.00004362588,0.000007542575,0.00004581817,0.00002087334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002662712,0.0001055258,0.0001628825,0.01652009,0.0002538913,0.0001906973,0.00002200033,0.0003178302,0.001253779,0.001443042,0.03769874,0.9417652],"study_design_scores_gemma":[0.0002729714,0.0003458628,0.001836164,0.007420846,0.001192307,0.001653931,0.00005055038,0.0002365132,0.0007959402,0.002100793,0.9840523,0.0000418517],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009221191,0.9987761,0.00009584756,0.0002048788,0.0001700181,0.000004859025,0.00002553334,0.000006747787,0.0006237803],"genre_scores_gemma":[0.0006383782,0.99794,0.0002019561,0.0003832766,0.0002512738,0.00001000391,0.00005102522,0.000001581141,0.0005224788],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0043389,"threshold_uncertainty_score":0.01451504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02531221074438224,"score_gpt":0.3063807231256267,"score_spread":0.2810685123812445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}