{"id":"W4406937636","doi":"10.1101/2025.01.28.25321238","title":"Prognostic value of admission H3.1 nucleosome levels in sepsis-associated acute kidney injury: a secondary analysis of the SISPCT randomised clinical trial","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Acute Kidney Injury Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"South East Physics Network; Deutsche Forschungsgemeinschaft","keywords":"Acute kidney injury; Medicine; Internal medicine; Value (mathematics); Sepsis; Randomized controlled trial; Intensive care medicine; Emergency medicine; Oncology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005503098,0.001377029,0.003633588,0.0004488221,0.0003554666,0.001736752,0.0007719844,0.00137923,0.003742033],"category_scores_gemma":[0.007638529,0.0004296631,0.00461561,0.000712916,0.000713846,0.001055563,0.000840659,0.002122374,0.0003055691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006609295,"about_ca_system_score_gemma":0.001008719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006877181,"about_ca_topic_score_gemma":0.0008845882,"domain_scores_codex":[0.9957823,0.00295757,0.000274933,0.0004926062,0.0002402229,0.0002524566],"domain_scores_gemma":[0.9914439,0.003658816,0.002428787,0.0007246364,0.000551126,0.001192684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9556031,0.0004821366,0.02357715,0.001336813,0.01006583,0.00009020741,0.00004376296,0.0007899265,0.0007268107,0.0001680483,0.001288232,0.005828024],"study_design_scores_gemma":[0.7239705,0.05123407,0.1846183,0.0005906392,0.0252157,0.0003715684,0.0001483228,0.008333726,0.001212074,0.001764179,0.002383255,0.0001577793],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891343,0.005511105,0.0005437763,0.0005290175,0.000335414,0.0005054754,0.002419244,0.00003748247,0.0009842181],"genre_scores_gemma":[0.9949836,0.0007137748,0.0003760156,0.0002683032,0.0003241104,0.0005358388,0.002287786,0.00001194852,0.0004986267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005503098,"threshold_uncertainty_score":0.02910352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06578792674697159,"score_gpt":0.4201303882345285,"score_spread":0.3543424614875569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}